Maria T Huayllani1, David J Restrepo1, Daniel Boczar1, Andrea Sisti1, Aaron C Spaulding2, Alexander S Parker3, Rachel Sarabia-Estrada4, Hugo Guerrero-Cazares4, Steven L Moran5, Antonio J Forte6. 1. Division of Plastic Surgery and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Jacksonville, FL, U.S.A. 2. Department of Health Science Research, Mayo Clinic, Jacksonville, FL, U.S.A. 3. University of Florida, College of Medicine, Jacksonville, FL, U.S.A. 4. Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, U.S.A. 5. Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, MN, U.S.A. 6. Division of Plastic Surgery and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Jacksonville, FL, U.S.A. ajvforte@yahoo.com.br.
Abstract
BACKGROUND/AIM: Osteosarcoma of the upper extremities is rare, and characteristics in this location have not been described before. We aimed to analyze the characteristics and survival rate of osteosarcoma of the upper extremities. MATERIALS AND METHODS: A retrospective cohort study was performed by querying the National Cancer Database. Statistical analysis was performed using a multivariate logistic regression model and Kaplan-Meier log-rank tests for survival. RESULTS: A total of 991 patients were diagnosed with osteosarcoma of the upper extremities. Most tumors were osteogenic and osteoblastic (66.8%), larger than 8 cm (47.9%), high grade (64.3%), lymph node-negative (7.9%), and without metastasis to lungs (39.0%). Osteosarcomas of the hand and wrist were less likely to be high-grade when compared to osteosarcomas of the forearm, arm, and shoulder. CONCLUSION: The results of this study help us to approach patients promptly and avoid total amputation, increasing functionality and prognosis of the disease. Copyright
BACKGROUND/AIM: Osteosarcoma of the upper extremities is rare, and characteristics in this location have not been described before. We aimed to analyze the characteristics and survival rate of osteosarcoma of the upper extremities. MATERIALS AND METHODS: A retrospective cohort study was performed by querying the National Cancer Database. Statistical analysis was performed using a multivariate logistic regression model and Kaplan-Meier log-rank tests for survival. RESULTS: A total of 991 patients were diagnosed with osteosarcoma of the upper extremities. Most tumors were osteogenic and osteoblastic (66.8%), larger than 8 cm (47.9%), high grade (64.3%), lymph node-negative (7.9%), and without metastasis to lungs (39.0%). Osteosarcomas of the hand and wrist were less likely to be high-grade when compared to osteosarcomas of the forearm, arm, and shoulder. CONCLUSION: The results of this study help us to approach patients promptly and avoid total amputation, increasing functionality and prognosis of the disease. Copyright
Authors: Rebekka Götzl; Sebastian Sterzinger; Andreas Arkudas; Anja M Boos; Sabine Semrau; Nikolaos Vassos; Robert Grützmann; Abbas Agaimy; Werner Hohenberger; Raymund E Horch; Justus P Beier Journal: Cancers (Basel) Date: 2020-11-26 Impact factor: 6.639