John Papaggelopoulos1, Antonia Angelopoulou2,3, Dimitris Avgoustidis4, Nikolas Koronellos1, Spyridoula Derka1, Stavros Vassiliou1, Christos Yapijakis5,2,3. 1. Department of Oral and Maxillofacial Surgery, School of Medicine, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece. 2. Unit of Orofacial Genetics, 1st Department of Pediatrics, School of Medicine, "Agia Sophia" Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece. 3. Department of Molecular Genetics, "Cephalogenetics" Center, Athens, Greece. 4. Department of Oral and Maxillofacial Surgery, Evangelismos General Hospital, Athens, Greece. 5. Department of Oral and Maxillofacial Surgery, School of Medicine, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece cyapi@med.uoa.gr.
Abstract
BACKGROUND/AIM: Basal cell carcinoma (BCC) has been genetically associated with an increased expression of angiotensin-converting enzyme (ACE), an important factor of the renin-angiotensin system which produces vasoconstrictor angiotensin II. Other factors of this system include angiotensinogen (AGT) and angiotensin receptors AGTR1, AGTR2. We investigated the possible association of BCC with genetic variability in the AGT, AGTR1 and AGTR2 genes. MATERIALS AND METHODS: DNA samples of 190 Greeks were studied, including 91 patients with BCC and 99 matched healthy controls. Molecular genotyping of patients and controls was performed for the polymorphisms AGT M235T, AGTR1 A1166C and AGTR2 G1675A. RESULTS: The mutant T allele that increases AGT gene expression was detected in two-fold increased frequency in BCC patients in comparison to healthy controls (p <0.001). On the contrary, no significant difference was observed in AGTR1 and AGTR2 variants between patients and controls. CONCLUSION: Increased expression of AGT may be associated with BCC. Copyright
BACKGROUND/AIM: Basal cell carcinoma (BCC) has been genetically associated with an increased expression of angiotensin-converting enzyme (ACE), an important factor of the renin-angiotensin system which produces vasoconstrictor angiotensin II. Other factors of this system include angiotensinogen (AGT) and angiotensin receptors AGTR1, AGTR2. We investigated the possible association of BCC with genetic variability in the AGT, AGTR1 and AGTR2 genes. MATERIALS AND METHODS: DNA samples of 190 Greeks were studied, including 91 patients with BCC and 99 matched healthy controls. Molecular genotyping of patients and controls was performed for the polymorphisms AGTM235T, AGTR1A1166C and AGTR2G1675A. RESULTS: The mutant T allele that increases AGT gene expression was detected in two-fold increased frequency in BCCpatients in comparison to healthy controls (p <0.001). On the contrary, no significant difference was observed in AGTR1 and AGTR2 variants between patients and controls. CONCLUSION: Increased expression of AGT may be associated with BCC. Copyright