Literature DB >> 3156965

Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT.

S Hjorth.   

Abstract

The potent, centrally acting 5-HT receptor agonist 8-OH-DPAT was shown to induce a clearcut hypothermic response in naive and PCPA-pretreated conscious rats, maintained at 22 degrees C. PCPA pretreatment decreased the threshold dose of 8-OH-DPAT required to cause hypothermia, indicating that a sensitisation of 5-HT-receptor dependent mechanisms was involved. The results are discussed with reference to recent 5-HT receptor subclassification. It is suggested that body temperature measurements in the rat might provide a simple in vivo physiological means of studying central serotoninergic mechanisms, including 5-HT receptor sensitivity modification.

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Year:  1985        PMID： 3156965     DOI： 10.1007/bf01253058

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  5 in total

1.  8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.

Authors:  D N Middlemiss; J R Fozard
Journal:  Eur J Pharmacol       Date:  1983-05-20       Impact factor: 4.432

2.  8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.

Authors:  L E Arvidsson; U Hacksell; J L Nilsson; S Hjorth; A Carlsson; P Lindberg; D Sanchez; H Wikstrom
Journal:  J Med Chem       Date:  1981-08       Impact factor: 7.446

3.  Elevating serotonin levels in brain with 5-hydroxytryptophan produces hypothermia in rats.

Authors:  M T Lin; C F Chow; Y F Chern; K M Wu
Journal:  Pflugers Arch       Date:  1978-11-30       Impact factor: 3.657

4.  Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat.

Authors:  I Lucki; M S Nobler; A Frazer
Journal:  J Pharmacol Exp Ther       Date:  1984-01       Impact factor: 4.030

5.  Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT.

Authors:  H Gozlan; S El Mestikawy; L Pichat; J Glowinski; M Hamon
Journal:  Nature       Date:  1983 Sep 8-14       Impact factor: 49.962
  5 in total
  46 in total

1.  Species differences in the mechanism through which the serotonergic agonists indorenate and ipsapirone produce their anxiolytic action.

Authors:  A Fernández-Guasti; E Hong; C López-Rubalcava
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  Flibanserin and 8-OH-DPAT implicate serotonin in association between female marmoset monkey sexual behavior and changes in pair-bond quality.

Authors:  Yves Aubert; Morgan L Gustison; Lindsey A Gardner; Michael A Bohl; Jason R Lange; Kelly A Allers; Bernd Sommer; Nicole A Datson; David H Abbott
Journal:  J Sex Med       Date:  2012-02-03       Impact factor: 3.802

3.  Mast cells are necessary for the hypothermic response to LPS-induced sepsis.

Authors:  Katherine M Nautiyal; Heather McKellar; Ann-Judith Silverman; Rae Silver
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-12-24       Impact factor: 3.619

4.  Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers.

Authors:  I M Anderson; P J Cowen
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

5.  Central efferent pathways for cold-defensive and febrile shivering.

Authors:  Kazuhiro Nakamura; Shaun F Morrison
Journal:  J Physiol       Date:  2011-05-24       Impact factor: 5.182

6.  Evidence for selective inhibition of limbic forebrain dopamine synthesis by 8-OH-DPAT in the rat.

Authors:  S Ahlenius; V Hillegaart; A Wijkström
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-05       Impact factor: 3.000

7.  Chronic lithium treatment enhances the postsynaptic 5-HT1A receptor-mediated 5-HT behavioral syndrome induced by 8-OH-DPAT in rats via catecholaminergic systems.

Authors:  Y Uchitomi; S Yamawaki
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

8.  Counteraction of the rapid tolerance to 8-OH-DPAT-induced corticosterone secretion in rats by activation of the GABAA receptor-chloride channel complex.

Authors:  D Kelder; S B Ross
Journal:  Br J Pharmacol       Date:  1993-05       Impact factor: 8.739

9.  Clozapine and olanzapine, but not haloperidol, reverse cold-induced and lipopolysaccharide-induced cutaneous vasoconstriction.

Authors:  William Walter Blessing
Journal:  Psychopharmacology (Berl)       Date:  2004-10       Impact factor: 4.530

10.  Differential effects of acute and repeated citalopram in mouse models of anxiety and depression.

Authors:  Cedric Mombereau; Tamar L Gur; Jennifer Onksen; Julie A Blendy
Journal:  Int J Neuropsychopharmacol       Date:  2009-12-14       Impact factor: 5.176
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