Hyungjin Kim1, Jin Mo Goo2, Young Tae Kim3, Chang Min Park4. 1. Department of Radiology, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea; Institute of Radiation Medicine, Seoul National University Medical Research Center, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. 2. Department of Radiology, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea; Institute of Radiation Medicine, Seoul National University Medical Research Center, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea; Cancer Research Institute, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. 3. Cancer Research Institute, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea; Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. 4. Department of Radiology, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea; Institute of Radiation Medicine, Seoul National University Medical Research Center, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea; Cancer Research Institute, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. Electronic address: cmpark.morphius@gmail.com.
Abstract
OBJECTIVES: Our study aimed to investigate the independent prognostic values of consolidation-to-tumor ratio (CTR) and tumor disappearance ratio (TDR) after adjustment for the conventional prognostic factors and the eighth edition clinical T category for patients with resected lung adenocarcinomas. MATERIALS AND METHODS: This retrospective study included 691 patients (281 men and 410 women; median age, 63 years) with resected lung adenocarcinomas (clinical T1N0M0). The prognostic implications for disease-free survival (DFS) of CTR and TDR in continuous and categorical forms were analyzed using multivariable-adjusted Cox regression analysis, including multiple clinico-radiological prognostic factors and the clinical T category based on the solid portion measurement. Analysis was performed for the total study population and for two part-solid nodule subgroups (cT1mi/cT1a to cT1c and cT1mi/cT1a to cT1b, respectively). RESULTS: For the total study population, CTR and TDR were not selected in the multivariable Cox regression models, which indicated that these are not independent prognostic factors. Age (adjusted HR: 1.026; P = 0.022) and clinical T category (adjusted HR for cT1b: 3.475; P = 0.019; adjusted HR for cT1c: 9.938; P < 0.001) were independently associated with DFS. For the part-solid nodule subgroups, multivariable-adjusted HRs for CTR and TDR were not statistically significant (all P > 0.05). CONCLUSION: CTR and TDR were not independent prognostic factors. Preoperative prognostication based on clinical T category would be sufficient without further stratification according to CTR or TDR.
OBJECTIVES: Our study aimed to investigate the independent prognostic values of consolidation-to-tumor ratio (CTR) and tumor disappearance ratio (TDR) after adjustment for the conventional prognostic factors and the eighth edition clinical T category for patients with resected lung adenocarcinomas. MATERIALS AND METHODS: This retrospective study included 691 patients (281 men and 410 women; median age, 63 years) with resected lung adenocarcinomas (clinical T1N0M0). The prognostic implications for disease-free survival (DFS) of CTR and TDR in continuous and categorical forms were analyzed using multivariable-adjusted Cox regression analysis, including multiple clinico-radiological prognostic factors and the clinical T category based on the solid portion measurement. Analysis was performed for the total study population and for two part-solid nodule subgroups (cT1mi/cT1a to cT1c and cT1mi/cT1a to cT1b, respectively). RESULTS: For the total study population, CTR and TDR were not selected in the multivariable Cox regression models, which indicated that these are not independent prognostic factors. Age (adjusted HR: 1.026; P = 0.022) and clinical T category (adjusted HR for cT1b: 3.475; P = 0.019; adjusted HR for cT1c: 9.938; P < 0.001) were independently associated with DFS. For the part-solid nodule subgroups, multivariable-adjusted HRs for CTR and TDR were not statistically significant (all P > 0.05). CONCLUSION: CTR and TDR were not independent prognostic factors. Preoperative prognostication based on clinical T category would be sufficient without further stratification according to CTR or TDR.
Authors: Teng Zhang; Chengxiu Zhang; Yan Zhong; Yingli Sun; Haijie Wang; Hai Li; Guang Yang; Quan Zhu; Mei Yuan Journal: Front Oncol Date: 2022-08-11 Impact factor: 5.738