Literature DB >> 3156805

Randomised comparative study of ceftriaxone and spectinomycin in gonorrhoea.

K Panikabutra, C Ariyarit, A Chitwarakorn, C Saensanoh, C Wongba.   

Abstract

From 26 April to 30 June 1983 a total of 200 men with uncomplicated gonococcal urethritis were randomly treated with either 2 g spectinomycin or 250 mg ceftriaxone, both administered intramuscularly. Of 197 isolates tested for the presence of the enzyme beta lactamase, 91 (46.2%) were positive (PPNG) and 106 (53.8%) were non-PPNG strains. All 93 patients treated with spectinomycin and followed up and 97 treated with ceftriaxone and followed up were cured. Ceftriaxone 250 mg administered by intramuscular injection is highly effective in treating gonococcal infections caused by both PPNG and non-PPNG strains and is an appropriate alternative to spectinomycin.

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Year:  1985        PMID： 3156805      PMCID： PMC1011777          DOI： 10.1136/sti.61.2.106

Source DB:  PubMed          Journal:  Genitourin Med        ISSN： 0266-4348


  17 in total

1.  Spectinomycin-resistant penicillinase-producing Neisseria gonorrhoeae--California.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  1981-05-22       Impact factor: 17.586

2.  Cefoxitin as a single-dose treatment for urethritis caused by penicillinase-producing Neisseria gonorrhoeae.

Authors:  S W Berg; M E Kilpatrick; W O Harrison; J A McCutchan
Journal:  N Engl J Med       Date:  1979-09-06       Impact factor: 91.245

3.  Cefoxitin in the treatment of gonorrhea.

Authors:  R B Jones; J Stimson; G W Counts; K K Holmes
Journal:  Sex Transm Dis       Date:  1979 Oct-Dec       Impact factor: 2.830

4.  National gonorrhea therapy monitoring study: treatment results.

Authors:  R E Kaufman; R E Johnson; H W Jaffe; C Thornsberry; G H Reynolds; P J Wiesner
Journal:  N Engl J Med       Date:  1976-01-01       Impact factor: 91.245

5.  Ro 13-9904, a long-acting broad-spectrum cephalosporin: in vitro and in vivo studies.

Authors:  P Angehrn; P J Probst; R Reiner; R L Then
Journal:  Antimicrob Agents Chemother       Date:  1980-12       Impact factor: 5.191

6.  HR 756--a new cephalosporin in the treatment of gonorrhoea caused by ordinary and penicillinase-producing strains of Neisseria gonorrhoeae.

Authors:  V S Rajan; E H Sng; R Pang; N J Tan; T Thirumoorthy; K L Yeo
Journal:  Br J Vener Dis       Date:  1980-08

7.  Comparative study of ceftriaxone and spectinomycin for treatment of uncomplicated gonorrhoea in men.

Authors:  H H Handsfield; V L Murphy
Journal:  Lancet       Date:  1983-07-09       Impact factor: 79.321

8.  Treatment of uncomplicated gonorrhea with cefotaxime.

Authors:  H H Handsfield; K K Holmes
Journal:  Sex Transm Dis       Date:  1981 Jul-Sep       Impact factor: 2.830

9.  Pharmacokinetics of ceftriaxone in humans.

Authors:  I H Patel; S Chen; M Parsonnet; M R Hackman; M A Brooks; J Konikoff; S A Kaplan
Journal:  Antimicrob Agents Chemother       Date:  1981-11       Impact factor: 5.191

10.  Comparative in vitro activity of 8 cephalosporins on 109 strains of Neisseria gonorrhoeae and 60 strains of Neisseria meningitidis.

Authors:  A Thabaut; J L Durosoir; P Saliou
Journal:  Chemotherapy       Date:  1981       Impact factor: 2.544
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  5 in total

1.  Randomised observer blind comparative trial of ceftriaxone and penicillin in treating uncomplicated gonorrhoea in men and women.

Authors:  C A Dixon; J B Bittiner; M Shahidullah; R C Slack; M Z Sulaiman
Journal:  Genitourin Med       Date:  1986-04

Review 2.  Ceftriaxone. A reappraisal of its antibacterial activity and pharmacokinetic properties, and an update on its therapeutic use with particular reference to once-daily administration.

Authors:  R N Brogden; A Ward
Journal:  Drugs       Date:  1988-06       Impact factor: 9.546

3.  Efficacy of ofloxacin in uncomplicated gonorrhoea.

Authors:  C Ariyarit; K Panikabutra; A Chitwarakorn; C Wongba; A Buatiang
Journal:  Infection       Date:  1986       Impact factor: 3.553

4.  Treating genitourinary and pharyngeal gonorrhoea with single dose ceftriaxone.

Authors:  J Christophersen; A C Bollerup; E From; J O Rønne-Rasmussen; K Quitzau
Journal:  Genitourin Med       Date:  1989-01

5.  Efficacy and Safety of Injectable and Oral Antibiotics in Treating Gonorrhea: A Systematic Review and Network Meta-Analysis.

Authors:  Jiaru Yang; Subhash Dhital; Thomas Naderer
Journal:  J Clin Med       Date:  2019-12-11       Impact factor: 4.241
  5 in total

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