Literature DB >> 3156765

Deoxynojirimycin inhibits the formation of Glc3Man9GlcNAc2-PP-dolichol in intestinal epithelial cells in culture.

P A Romero, P Friedlander, A Herscovics.   

Abstract

The lipid-linked oligosaccharides synthesized in the presence of the alpha-glucosidase inhibitors, 1-deoxynojirimycin (DJN) and N-methyl-1-deoxynojirimycin (MDJN), were compared in IEC-6 intestinal epithelial cells in culture. HPLC analysis of the oligosaccharides obtained before and after exhaustive jack bean alpha-mannosidase digestion indicates that control and MDJN-treated cells synthesize similar amounts of Glc3Man9GlcNAc2-PP-dolichol. In contrast, the formation of this compound is greatly reduced in DJN-treated cells, the major lipid-linked oligosaccharide found being Man9GlcNAc2-PP-dolichol. The decreased availability of the preferred donor for protein glycosylation may account for the impaired glycosylation and secretion of certain glycoproteins in the presence of DJN.

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Year:  1985        PMID： 3156765     DOI： 10.1016/0014-5793(85)80947-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Aminosugar derivatives as potential anti-human immunodeficiency virus agents.

Authors:  A Karpas; G W Fleet; R A Dwek; S Petursson; S K Namgoong; N G Ramsden; G S Jacob; T W Rademacher
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

2.  Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.

Authors:  D C Montefiori; W E Robinson; W M Mitchell
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

3.  Expression of the Saccharomyces cerevisiae glycoprotein invertase in mouse fibroblasts: glycosylation, secretion, and enzymatic activity.

Authors:  M L Bergh; C L Cepko; D Wolf; P W Robbins
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

4.  Different effects of the glucosidase inhibitors 1-deoxynojirimycin, N-methyl-1-deoxynojirimycin and castanospermine on the glycosylation of rat alpha 1-proteinase inhibitor and alpha 1-acid glycoprotein.

Authors:  V Gross; T A Tran-Thi; R T Schwarz; A D Elbein; K Decker; P C Heinrich
Journal:  Biochem J       Date:  1986-06-15       Impact factor: 3.857

5.  Inhibition of myoblast fusion by the glucosidase inhibitor N-methyl-1-deoxynojirimycin, but not by the mannosidase inhibitor 1-deoxymannojirimycin.

Authors:  P C Holland; A Herscovics
Journal:  Biochem J       Date:  1986-09-01       Impact factor: 3.857

6.  A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals.

Authors:  Michael D Rugen; Mathieu M J L Vernet; Laila Hantouti; Amalia Soenens; Vasilios M E Andriotis; Martin Rejzek; Paul Brett; Richard J B H N van den Berg; Johannes M F G Aerts; Hermen S Overkleeft; Robert A Field
Journal:  Sci Rep       Date:  2018-11-06       Impact factor: 4.379

Review 7.  Inhibitors of protein glycosylation and glycoprotein processing in viral systems.

Authors:  R Datema; S Olofsson; P A Romero
Journal:  Pharmacol Ther       Date:  1987       Impact factor: 12.310

Review 8.  Exploring the Potential of Chemical Inhibitors for Targeting Post-translational Glycosylation of Coronavirus (SARS-CoV-2).

Authors:  Nancy Tripathi; Bharat Goel; Nivedita Bhardwaj; Ram A Vishwakarma; Shreyans K Jain
Journal:  ACS Omega       Date:  2022-07-28

9.  Retention of glucose units added by the UDP-GLC:glycoprotein glucosyltransferase delays exit of glycoproteins from the endoplasmic reticulum.

Authors:  C Labriola; J J Cazzulo; A J Parodi
Journal:  J Cell Biol       Date:  1995-08       Impact factor: 10.539
  9 in total

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