Literature DB >> 3156751

Potentiation of beta-endorphin effects by proglumide in rats.

G Katsuura, S Itoh.   

Abstract

The effects of proglumide, a cholecystokinin (CCK) receptor antagonist, on the analgesia and catalepsy induced by beta-endorphin were investigated in rats. Proglumide itself produced a slight analgesia but no catalepsy. Combined intracerebroventricular administration of beta-endorphin and proglumide produced marked potentiation of the analgesic and cataleptic effects of beta-endorphin. The results suggest that endogenous CCK may have an antagonistic effect on the actions of beta-endorphin in the brain.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3156751     DOI： 10.1016/0014-2999(85)90263-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  3 in total

1.  PD134308, a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically interacts with intrathecal galanin to depress spinal nociceptive reflexes.

Authors:  Z Wiesenfeld-Hallin; X J Xu; J Hughes; D C Horwell; T Hökfelt
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

2.  CI988, a selective antagonist of cholecystokininB receptors, prevents morphine tolerance in the rat.

Authors:  X J Xu; Z Wiesenfeld-Hallin; J Hughes; D C Horwell; T Hökfelt
Journal:  Br J Pharmacol       Date:  1992-03       Impact factor: 8.739

3.  A locus and mechanism of action for associative morphine tolerance.

Authors:  J M Mitchell; A I Basbaum; H L Fields
Journal:  Nat Neurosci       Date:  2000-01       Impact factor: 24.884
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.