Joshua A Hill1,2,3. 1. Vaccine and Infectious Disease Division. 2. Clinical Research Division, Fred Hutchinson Cancer Research Center. 3. Department of Medicine, University of Washington, Seattle, Washington, USA.
Abstract
PURPOSE OF REVIEW: The current review article focuses on recent advances in the approach to the diagnosis and treatment of human herpesvirus 6B (HHV-6B) in hematopoietic cell and solid organ transplant recipients. RECENT FINDINGS: Over the past few years, key studies have broadened our understanding of best practices for the prevention and treatment of HHV-6B encephalitis after transplantation. Moreover, important data have been reported that support a potential role of HHV-6B reactivation in the development of acute graft-versus-host disease and lower respiratory tract disease in transplant recipients. Finally, increasing recognition of inherited chromosomally integrated HHV-6 (iciHHV-6) and an expanding array of diagnostic tools have increased our understanding of the potential for complications related to viral reactivation originating from iciHHV-6 in donors or recipients. SUMMARY: Recent advances in diagnostic tools, disease associations, and potential treatments for HHV-6B present abundant opportunities for improving our understanding and management of this complex virus in transplant recipients.
PURPOSE OF REVIEW: The current review article focuses on recent advances in the approach to the diagnosis and treatment of human herpesvirus 6B (HHV-6B) in hematopoietic cell and solid organ transplant recipients. RECENT FINDINGS: Over the past few years, key studies have broadened our understanding of best practices for the prevention and treatment of HHV-6B encephalitis after transplantation. Moreover, important data have been reported that support a potential role of HHV-6B reactivation in the development of acute graft-versus-host disease and lower respiratory tract disease in transplant recipients. Finally, increasing recognition of inherited chromosomally integrated HHV-6 (iciHHV-6) and an expanding array of diagnostic tools have increased our understanding of the potential for complications related to viral reactivation originating from iciHHV-6 in donors or recipients. SUMMARY: Recent advances in diagnostic tools, disease associations, and potential treatments for HHV-6B present abundant opportunities for improving our understanding and management of this complex virus in transplant recipients.
Authors: Danielle M Zerr; Michael Boeckh; Colleen Delaney; Paul J Martin; Hu Xie; Amanda L Adler; Meei-Li Huang; Lawrence Corey; Wendy M Leisenring Journal: Biol Blood Marrow Transplant Date: 2012-05-26 Impact factor: 5.742
Authors: Xiaofeng Zhou; David N O'Dwyer; Meng Xia; Holly K Miller; Paul R Chan; Kelsey Trulik; Mathew M Chadwick; Timothy C Hoffman; Camille Bulte; Kevin Sekerak; Carol A Wilke; Swapneel J Patel; Wayne M Yokoyama; Susan Murray; Gregory A Yanik; Bethany B Moore Journal: Am J Respir Crit Care Med Date: 2019-07-01 Impact factor: 21.405
Authors: K Ishiyama; T Katagiri; K Ohata; K Hosokawa; Y Kondo; H Yamazaki; A Takami; S Nakao Journal: Transpl Infect Dis Date: 2011-07-28 Impact factor: 2.228
Authors: Rick Admiraal; Coco C H de Koning; Caroline A Lindemans; Marc B Bierings; Annemarie M J Wensing; A Birgitta Versluys; Tom F W Wolfs; Stefan Nierkens; Jaap Jan Boelens Journal: J Allergy Clin Immunol Date: 2017-04-07 Impact factor: 10.793
Authors: Philip E Pellett; Dharam V Ablashi; Peter F Ambros; Henri Agut; Mary T Caserta; Vincent Descamps; Louis Flamand; Agnès Gautheret-Dejean; Caroline B Hall; Rammurti T Kamble; Uwe Kuehl; Dirk Lassner; Irmeli Lautenschlager; Kristin S Loomis; Mario Luppi; Paolo Lusso; Peter G Medveczky; Jose G Montoya; Yasuko Mori; Masao Ogata; Joshua C Pritchett; Sylvie Rogez; Edward Seto; Katherine N Ward; Tetsushi Yoshikawa; Raymund R Razonable Journal: Rev Med Virol Date: 2011-11-04 Impact factor: 6.989
Authors: Katherine N Ward; Joshua A Hill; Petr Hubacek; Rafael de la Camara; Roberto Crocchiolo; Hermann Einsele; David Navarro; Christine Robin; Catherine Cordonnier; Per Ljungman Journal: Haematologica Date: 2019-08-29 Impact factor: 9.941
Authors: Tuan L Phan; Kristen Carlin; Per Ljungman; Ioannis Politikos; Vicki Boussiotis; Michael Boeckh; Michele L Shaffer; Danielle M Zerr Journal: Biol Blood Marrow Transplant Date: 2018-04-21 Impact factor: 5.742
Authors: Derek J Hanson; Hu Xie; Danielle M Zerr; Wendy M Leisenring; Keith R Jerome; Meei-Li Huang; Terry Stevens-Ayers; Michael Boeckh; David M Koelle; Joshua A Hill Journal: J Infect Dis Date: 2021-02-24 Impact factor: 5.226
Authors: Michael L Wood; Colin D Veal; Rita Neumann; Nicolás M Suárez; Jenna Nichols; Andrei J Parker; Diana Martin; Simon Pr Romaine; Veryan Codd; Nilesh J Samani; Adriaan A Voors; Maciej Tomaszewski; Louis Flamand; Andrew J Davison; Nicola J Royle Journal: Elife Date: 2021-09-21 Impact factor: 8.140
Authors: Madeleine R Heldman; Cassandra Job; Joyce Maalouf; Jessica Morris; Hu Xie; Chris Davis; Terry Stevens-Ayers; Meei-Li Huang; Keith R Jerome; Jesse R Fann; Danielle M Zerr; Michael Boeckh; Joshua A Hill Journal: Transplant Cell Ther Date: 2021-06-07