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Literature DB >> 3156615

Strength of the human mixed lymphocyte reaction (MLR) and its suppression by azathioprine or 6-mercaptopurine.

Abstract

Azathioprine (36 microM) had a significantly (P less than 0.00003) greater inhibitory effect on human MLR responses below 20,000 counts/min than on responses above 20,000 counts/min. In contrast, 6-mercaptopurine (100 microM) had a similar suppressive effect on MLR responses below and above 20,000 counts/min suggesting it has a different mode of action to azathioprine.

Entities: Chemical Species

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Year: 1985 PMID： 3156615 PMCID： PMC1463800 DOI： 10.1111/j.1365-2125.1985.tb02622.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

14 in total

1. The correlation of tissue typing, mixed lymphocyte culture, and related donor renal allograft survival.

Authors: J Cerilli; Y G Newhouse; M A Williams
Journal: Transplant Proc Date: 1978-12 Impact factor: 1.066

2. Rapid mixed lymphocyte culture (MLC)--an aid for selection of recipients of cadaveric renal allografts.

Authors: K M Butt; N R Glass; I Parsa; T K Rao; R J Adamsons; S L Kountz
Journal: Transplant Proc Date: 1979-03 Impact factor: 1.066

3. Mixed lymphocyte reaction and graft survival in forty cadaveric renal transplants.

Authors: P R Cullen; S Lester; J Rouch; P J Morris
Journal: Clin Exp Immunol Date: 1977-05 Impact factor: 4.330

4. Role of MLC compatibility in intrafamilial kidney transplantation.

Authors: O Ringdén; E Möller; G Lundgren; C G Groth
Journal: Transplantation Date: 1976-07 Impact factor: 4.939

5. The correlation of MLC with graft survival.

Authors: K C Cochrum; H A Perkins; R O Payne; S L Kountz; F O Belzer
Journal: Transplant Proc Date: 1973-03 Impact factor: 1.066

6. A rapid MLC test for selection of allograft recipients for cadaveric kidneys.

Authors: K M Butt; I Parsa; S L Kountz
Journal: Surg Forum Date: 1973

7. Mixed lymphocyte culture, phytohemagglutinin stimulation, and matching grade: clinical relevance in renal transplantation from living related donors.

Authors: A A Pineda; S B Moore; J E Woods; K P Offord; H Zincke; H F Taswell
Journal: Transplantation Date: 1980-02 Impact factor: 4.939

Strength of the human mixed lymphocyte reaction (MLR) and its suppression by azathioprine or 6-mercaptopurine.

1. The correlation of tissue typing, mixed lymphocyte culture, and related donor renal allograft survival.

2. Rapid mixed lymphocyte culture (MLC)--an aid for selection of recipients of cadaveric renal allografts.

3. Mixed lymphocyte reaction and graft survival in forty cadaveric renal transplants.

4. Role of MLC compatibility in intrafamilial kidney transplantation.

5. The correlation of MLC with graft survival.

6. A rapid MLC test for selection of allograft recipients for cadaveric kidneys.

7. Mixed lymphocyte culture, phytohemagglutinin stimulation, and matching grade: clinical relevance in renal transplantation from living related donors.

8. Azathioprine and 6-mercaptopurine (6-MP) suppress the human mixed lymphocyte reaction (MLR) by different mechanisms.

9. Correlation between MLC stimulation and graft survival in living related and cadaver transplants.

10. Transformation of lymphocytes from patients awaiting cadaver renal transplants.

1. Effect of interleukin-2 on the inhibition of the human mixed lymphocyte reaction (MLR) by azathioprine.