Literature DB >> 31566058

LncRNA NR2F2-AS1 positively regulates CDK4 to promote cancer cell proliferation in prostate carcinoma.

Xiaoliang Fu1, Dong Wang1, Tao Shu1, Dong Cui1, Qiang Fu1.   

Abstract

We in this study investigated the role of lncRNA NR2F2-AS1 in prostate carcinoma (PC). We showed that NR2F2-AS1 was upregulated in PC and positively correlated with CDK4. In PC cells, NR2F2-AS1 overexpression led to upregulated, while NR2F2-AS1 siRNA silencing led to downregulated CDK4. Follow-up study revealed that high levels of NR2F2-AS1 and CDK4 in PC tissues were closely correlated with the poor survival of PC patients. Cell proliferation data showed that NR2F2-AS1 overexpression led to increased, while NR2F2-AS1 siRNA silencing led to proliferation rate of PC cells. Moreover, NR2F2-AS1 also showed positive effects on cell cycle progression. In addition, CDK4 overexpression reduced the effects of NR2F2-AS1 siRNA silencing. Therefore, NR2F2-AS1 positively regulates CDK4 to promote cancer cell proliferation in PC.

Entities:  

Keywords:  CDK4; NR2F2-AS1; proliferation; prostate carcinoma

Mesh：

Substances：

Year:  2019        PMID： 31566058     DOI： 10.1080/13685538.2019.1670157

Source DB:  PubMed          Journal:  Aging Male        ISSN： 1368-5538            Impact factor:   5.892


  7 in total

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Review 3.  A review on the role of cyclin dependent kinases in cancers.

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4.  Long non-coding RNA NR2F2-AS1 regulates human osteosarcoma growth and metastasis through miR-425-5p-mediated HMGB2.

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Review 5.  The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells.

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Review 6.  Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention.

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Journal:  J Exp Clin Cancer Res       Date:  2022-07-01

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Authors:  Dan Liu; Kejin Huang; Tiaojiao Wang; Xufeng Zhang; Wentao Liu; Xiaolong Yue; Jin Wu
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  7 in total

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