Victoria A Catenacci1,2, Danielle M Ostendorf1,2, Zhaoxing Pan3, Kristen Bing1,2, Liza T Wayland1,2, Emmanuel Seyoum1, Brian L Stauffer4, Suzanne Phelan5, Seth A Creasy1,2, Ann E Caldwell1,2, Holly R Wyatt1,2, Daniel H Bessesen1,2, Edward L Melanson2,6,7. 1. Department of Medicine, Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. 2. Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. 3. Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. 4. Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. 5. Department of Kinesiology and Public Health and Center for Health Research, California Polytechnic State University, San Luis Obispo, California, USA. 6. Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. 7. Eastern Colorado Veterans Affairs Geriatric Research, Education, and Clinical Center, Denver, Colorado, USA.
Abstract
OBJECTIVE: This study aimed to evaluate the impact of timing of exercise initiation on weight loss within a behavioral weight loss program. METHODS:Adults with overweight or obesity (N = 170; age 18-55 years; BMI 25-42 kg/m2 ; 83.5% women) were enrolled in an 18-month behavioral weight loss program consisting of a reduced-calorie diet, exercise, and group-based support. The standard group (STD) received a supervised exercise program (progressing to 300 min/wk of moderate-intensity aerobic exercise) during months 0 to 6. The sequential group (SEQ) was asked to refrain from changing exercise during months 0 to 6 and received the supervised exercise program during months 7 to 12. On completion of supervised exercise, both groups were instructed to continue 300 min/wk of moderate-intensity exercise for the study duration. RESULTS: At 6 months, the STD group exhibited greater reductions in body weight (-8.7 ± 0.7 kg) compared with the SEQ group (-6.9 ± 0.6 kg; P = 0.047). Between 6 and 18 months, the STD group regained more weight (2.5 ± 0.8 kg vs. 0.0 ± 0.8 kg; P = 0.02). At 18 months, there were no between-group differences in changes in weight (STD: -6.9 ± 1.2 kg; SEQ: -7.9 ± 1.2 kg), fat mass, lean mass, physical activity, or attrition. CONCLUSIONS: Both immediate and delayed exercise initiation within a behavioral weight loss program resulted in clinically meaningful weight loss at 18 months. Thus, timing of exercise initiation can be personalized based on patient preference.
RCT Entities:
OBJECTIVE: This study aimed to evaluate the impact of timing of exercise initiation on weight loss within a behavioral weight loss program. METHODS: Adults with overweight or obesity (N = 170; age 18-55 years; BMI 25-42 kg/m2 ; 83.5% women) were enrolled in an 18-month behavioral weight loss program consisting of a reduced-calorie diet, exercise, and group-based support. The standard group (STD) received a supervised exercise program (progressing to 300 min/wk of moderate-intensity aerobic exercise) during months 0 to 6. The sequential group (SEQ) was asked to refrain from changing exercise during months 0 to 6 and received the supervised exercise program during months 7 to 12. On completion of supervised exercise, both groups were instructed to continue 300 min/wk of moderate-intensity exercise for the study duration. RESULTS: At 6 months, the STD group exhibited greater reductions in body weight (-8.7 ± 0.7 kg) compared with the SEQ group (-6.9 ± 0.6 kg; P = 0.047). Between 6 and 18 months, the STD group regained more weight (2.5 ± 0.8 kg vs. 0.0 ± 0.8 kg; P = 0.02). At 18 months, there were no between-group differences in changes in weight (STD: -6.9 ± 1.2 kg; SEQ: -7.9 ± 1.2 kg), fat mass, lean mass, physical activity, or attrition. CONCLUSIONS: Both immediate and delayed exercise initiation within a behavioral weight loss program resulted in clinically meaningful weight loss at 18 months. Thus, timing of exercise initiation can be personalized based on patient preference.
Authors: Ann E Caldwell; Adnin Zaman; Danielle M Ostendorf; Zhaoxing Pan; Bryan B Swanson; Suzanne Phelan; Holly R Wyatt; Daniel H Bessesen; Edward L Melanson; Victoria A Catenacci Journal: Obesity (Silver Spring) Date: 2020-06 Impact factor: 5.002
Authors: Seth A Creasy; Danielle M Ostendorf; Jennifer M Blankenship; Laura Grau; Jaron Arbet; Daniel H Bessesen; Edward L Melanson; Victoria A Catenacci Journal: Int J Obes (Lond) Date: 2022-05-16 Impact factor: 5.551
Authors: Zhaoxing Pan; Dan Forjan; Tyson Marden; Jonathan Padia; Tonmoy Ghosh; Delwar Hossain; J Graham Thomas; Megan A McCrory; Edward Sazonov; Janine A Higgins Journal: Front Nutr Date: 2022-06-22
Authors: Bridget A Matikainen-Ankney; Mohamed A Ali; Nanami L Miyazaki; Sydney A Fry; Julia A Licholai; Alexxai V Kravitz Journal: Obesity (Silver Spring) Date: 2020-03-05 Impact factor: 9.298
Authors: Danielle M Ostendorf; Sarah J Schmiege; David E Conroy; Suzanne Phelan; Angela D Bryan; Victoria A Catenacci Journal: Int J Behav Nutr Phys Act Date: 2021-12-04 Impact factor: 6.457
Authors: Danielle M Ostendorf; Jennifer M Blankenship; Laura Grau; Jaron Arbet; Nia S Mitchell; Seth A Creasy; Ann E Caldwell; Edward L Melanson; Suzanne Phelan; Daniel H Bessesen; Victoria A Catenacci Journal: Obes Sci Pract Date: 2021-05-19
Authors: Laura Grau; Jaron Arbet; Danielle M Ostendorf; Jennifer M Blankenship; Shelby L Panter; Victoria A Catenacci; Edward L Melanson; Seth A Creasy Journal: Sleep Sci Date: 2022 Jul-Sep