| Literature DB >> 31563333 |
Susan R Mendley1, Adeera Levin2, Ricardo Correa-Rotter3, Bonnie R Joubert4, Elizabeth A Whelan5, Brian Curwin5, Erik H Koritzinsky6, Denise M Gaughan6, Paul L Kimmel6, Shuchi Anand7, Pedro Ordunez8, Ludovic Reveiz9, Diane S Rohlman10, Madeleine K Scammell11, Robert O Wright12, Robert A Star6.
Abstract
In June 2018, the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Environmental Health Sciences sponsored a workshop to identify research gaps in an increasingly common form of chronic kidney disease in agricultural communities, often termed "CKDu." The organizers invited a broad range of experts who provided diverse expertise and perspectives, many of whom had never addressed this particular epidemic. Discussion was focused around selected topics, including identifying and mitigating barriers to research in CKDu, creating a case definition, and defining common data elements. All hypotheses regarding etiology were entertained, and meeting participants discussed potential research strategies, choices in study design, and novel tools that may prove useful in this disease. Achievements of the workshop included robust cross-disciplinary discussion and preliminary planning of research goals and design. Specific challenges in implementing basic and clinical research and interventions in low- and middle-income countries were recognized. A balanced approach to leveraging local resources and capacity building without overreaching was emphasized. Published by Elsevier Inc.Entities:
Keywords: Mesoamerican nephropathy; chronic interstitial nephritis of agricultural communities; chronic kidney disease of uncertain/nontraditional etiology; environmental exposure; kidney disease of unknown cause in agricultural laborers; low- and middle-income countries; tubulointerstitial
Mesh:
Year: 2019 PMID: 31563333 PMCID: PMC7012362 DOI: 10.1016/j.kint.2019.06.024
Source DB: PubMed Journal: Kidney Int ISSN: 0085-2538 Impact factor: 10.612