Literature DB >> 31563278

Epithelial keratins: Biology and implications as diagnostic markers for liquid biopsies.

Stefan Werner1, Laura Keller1, Klaus Pantel2.   

Abstract

Keratins are essential elements of the cytoskeleton of normal and malignant epithelial cells. Because carcinomas commonly maintain their specific keratin expression pattern during malignant transformation, keratins are extensively used as tumor markers in cancer diagnosis including the detection of circulating tumor cells in blood of carcinoma patients. Interestingly, recent biological insights demonstrate that epithelial keratins should not only be considered as mere tumor markers. Emerging evidence suggests an active biological role of keratins in tumor cell dissemination and metastasis. In this review, we illustrate the family of keratin proteins, summarize the latest biological insights into keratin function related to cancer metastasis and discuss the current use of keratins for detection of CTCs and other blood biomarkers used in oncology.
Copyright © 2019. Published by Elsevier Ltd.

Entities:  

Keywords:  Circulating tumor cells; EMT; Keratins; Liquid biopsy; Tumor biomarker; Tumor cell dissemination

Mesh：

Substances：

Year:  2019        PMID： 31563278     DOI： 10.1016/j.mam.2019.09.001

Source DB:  PubMed          Journal:  Mol Aspects Med        ISSN： 0098-2997


  11 in total

Review 1.  Keratin 1 as a cell-surface receptor in cancer.

Authors:  Oluseye Ogunnigbagbe; Christopher G Bunick; Kamaljit Kaur
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2021-12-07       Impact factor: 11.414

2.  Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism.

Authors:  Krystal Ann Orlando; Amber K Douglas; Aierken Abudu; Yemin Wang; Basile Tessier-Cloutier; Weiping Su; Alec Peters; Larry S Sherman; Rayvon Moore; Vinh Nguyen; Gian Luca Negri; Shane Colborne; Gregg B Morin; Friedrich Kommoss; Jessica D Lang; William Pd Hendricks; Elizabeth A Raupach; Patrick Pirrotte; David G Huntsman; Jeffrey M Trent; Joel S Parker; Jesse R Raab; Bernard E Weissman
Journal:  Elife       Date:  2020-12-23       Impact factor: 8.140

3.  MACE RNA sequencing analysis of conjunctival squamous cell carcinoma and papilloma using formalin-fixed paraffin-embedded tumor tissue.

Authors:  Stefaniya Boneva; Anja Schlecht; Peipei Zhang; Daniel Boehringer; Thabo Lapp; Hans Mittelviefhaus; Thomas Reinhard; Claudia Auw-Haedrich; Guenther Schlunck; Julian Wolf; Clemens Lange
Journal:  Sci Rep       Date:  2020-12-04       Impact factor: 4.379

4.  Honokiol Inhibits Melanoma Growth by Targeting Keratin 18 in vitro and in vivo.

Authors:  Tingting Liu; Hui Liu; Penglei Wang; Yamei Hu; Ran Yang; Fangfang Liu; Hong Gyum Kim; Zigang Dong; Kangdong Liu
Journal:  Front Cell Dev Biol       Date:  2020-11-24

Review 5.  Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels.

Authors:  Stanley P Leong; Kamila Naxerova; Laura Keller; Klaus Pantel; Marlys Witte
Journal:  Clin Exp Metastasis       Date:  2021-11-12       Impact factor: 5.150

6.  High Keratin-7 Expression in Benign Peri-Tumoral Prostatic Glands Is Predictive of Bone Metastasis Onset and Prostate Cancer-Specific Mortality.

Authors:  Charles Dariane; Sylvie Clairefond; Benjamin Péant; Laudine Communal; Zhe Thian; Véronique Ouellet; Dominique Trudel; Nazim Benzerdjeb; Feryel Azzi; Arnaud Méjean; Marc-Olivier Timsit; Manon Baurès; Jacques-Emmanuel Guidotti; Vincent Goffin; Pierre I Karakiewicz; Anne-Marie Mes-Masson; Fred Saad
Journal:  Cancers (Basel)       Date:  2022-03-23       Impact factor: 6.639

Review 7.  Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments.

Authors:  Saife N Lone; Sabah Nisar; Tariq Masoodi; Mayank Singh; Arshi Rizwan; Sheema Hashem; Wael El-Rifai; Davide Bedognetti; Surinder K Batra; Mohammad Haris; Ajaz A Bhat; Muzafar A Macha
Journal:  Mol Cancer       Date:  2022-03-18       Impact factor: 27.401

8.  A Keratin 7 and E-Cadherin Signature Is Highly Predictive of Tubo-Ovarian High-Grade Serous Carcinoma Prognosis.

Authors:  Laudine Communal; Noemi Roy; Maxime Cahuzac; Kurosh Rahimi; Martin Köbel; Diane M Provencher; Anne-Marie Mes-Masson
Journal:  Int J Mol Sci       Date:  2021-05-18       Impact factor: 5.923

Review 9.  Keratin Biomaterials in Skin Wound Healing, an Old Player in Modern Medicine: A Mini Review.

Authors:  Marek Konop; Mateusz Rybka; Adrian Drapała
Journal:  Pharmaceutics       Date:  2021-11-28       Impact factor: 6.321

10.  Differences in Extracellular Vesicle Protein Cargo Are Dependent on Head and Neck Squamous Cell Carcinoma Cell of Origin and Human Papillomavirus Status.

Authors:  Christine Goudsmit; Felipe da Veiga Leprevost; Venkatesha Basrur; Lila Peters; Alexey Nesvizhskii; Heather Walline
Journal:  Cancers (Basel)       Date:  2021-07-23       Impact factor: 6.639
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