Zhaomin Xu1, Adan Z Becerra2, Carla F Justiniano1, Christopher T Aquina1, Fergal J Fleming1, Francis P Boscoe3, Maria J Schymura3, Abdulrahman K Sinno4, Jessica Chaoul5, Gary R Morrow6, Lori Minasian7, Sarah M Temkin8. 1. Department of Surgery, Surgical Health Outcomes and Research Enterprise, University of Rochester Medical Center, Rochester, New York. 2. Department of Surgery, Surgical Health Outcomes and Research Enterprise, University of Rochester Medical Center, Rochester, New York; Department of Public Health Sciences, Social & Scientific Systems, Silver Spring, Maryland. Electronic address: abecerra@s-3.com. 3. New York State Cancer Registry, New York State Department of Health, Albany, New York. 4. Department of Gynecology and Obstetrics, Olive View-UCLA Medical Center, Kagel Canyon, California. 5. Virginia Commonwealth University School of Medicine, Richmond, Virginia. 6. Department of Surgery, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York. 7. Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland. 8. Department of Ob/Gyn, Virginia Commonwealth University Medical Center, Richmond, Virginia.
Abstract
BACKGROUND: We examined factors associated with postoperative complications, 1-year overall and cancer-specific survival after epithelial ovarian cancer (EOC) diagnosis. METHODS: Patients who underwent surgery for EOC between 2004 and 2013 were included. Multivariable models analyzed postoperative complications, overall survival, and cancer-specific survival. RESULTS: Among 5223 patients, surgical complications were common. Postoperative complications correlated with increased odds of overall and disease-specific survival at 1 y. Receipt of chemotherapy was similar among women with and without postoperative complications and was independently associated with a reduction in the hazard of overall and disease-specific death at 1-year. Extensive pelvic and upper abdomen surgery resulted in 2.26 times the odds of postoperative complication, but was associated with longer 1-year overall 0.53 (0.35, 0.82) and disease-specific survival 0.54 (0.34, 0.85). CONCLUSIONS: Although extent of surgery was associated with complications, the survival benefit from comprehensive surgery offset the risk. Tailored surgical treatment for women with EOC may improve outcomes.
BACKGROUND: We examined factors associated with postoperative complications, 1-year overall and cancer-specific survival after epithelial ovarian cancer (EOC) diagnosis. METHODS:Patients who underwent surgery for EOC between 2004 and 2013 were included. Multivariable models analyzed postoperative complications, overall survival, and cancer-specific survival. RESULTS: Among 5223 patients, surgical complications were common. Postoperative complications correlated with increased odds of overall and disease-specific survival at 1 y. Receipt of chemotherapy was similar among women with and without postoperative complications and was independently associated with a reduction in the hazard of overall and disease-specific death at 1-year. Extensive pelvic and upper abdomen surgery resulted in 2.26 times the odds of postoperative complication, but was associated with longer 1-year overall 0.53 (0.35, 0.82) and disease-specific survival 0.54 (0.34, 0.85). CONCLUSIONS: Although extent of surgery was associated with complications, the survival benefit from comprehensive surgery offset the risk. Tailored surgical treatment for women with EOC may improve outcomes.
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