Literature DB >> 3156092

Analysis of the xenogeneic T-cell response to murine H-2 negative embryonal carcinoma cells.

R Aspinall, P L Stern.   

Abstract

Murine embryonal carcinoma cells are the stem cells of teratocarcinomas. They do not express H-2 antigens and previous reports have shown that these cells are not killed by major histocompatibility complex (MHC) restricted murine cytotoxic T cells. Here we report that effectors generated in MLCs between responders from a W3/13 enriched, NK-cell-depleted, rat spleen population, and spleen stimulators from 129 mice can lyse 129 embryonal carcinoma (EC) cells, but not CBA EC cells. A similar pattern of specific lysis of EC cells was seen with effectors generated in MLCs between rat lymph node and mouse spleen stimulators. Following priming in vivo with 129 EC cells, the frequency of cytotoxic T lymphocyte precursors against both 129 EC cells and 129 blast targets was increased when compared with the frequency found in age- and sex-matched unprimed animals. This response shows both specificity and memory and we conclude from this that it is due to rat T cells recognizing mouse xenogeneic antigens.

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Year:  1985        PMID： 3156092      PMCID： PMC1453533     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  23 in total

1.  MULTIPOTENTIALITY OF SINGLE EMBRYONAL CARCINOMA CELLS.

Authors:  L J KLEINSMITH; G B PIERCE
Journal:  Cancer Res       Date:  1964-10       Impact factor: 12.701

2.  Sensitivity of H-2-less target cells and role of H-2 in T-cell-mediated cytolysis.

Authors:  P Golstein; F Kelly; P Avner; G Gachelin
Journal:  Nature       Date:  1976-08-19       Impact factor: 49.962

3.  H-2 gene expression in required for T cell-mediated lysis of virus-infected target cells.

Authors:  P C Doherty; D Solter; B B Knowles
Journal:  Nature       Date:  1977-03-24       Impact factor: 49.962

4.  "Panning" for lymphocytes: a method for cell selection.

Authors:  L J Wysocki; V L Sato
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

5.  Letter: Absence of serologically detectable H-2 on primitive teratocarcinoma cells in culture.

Authors:  K Artzt; F Jacob
Journal:  Transplantation       Date:  1974-06       Impact factor: 4.939

Review 6.  Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control.

Authors:  R M Zinkernagel
Journal:  Immunol Rev       Date:  1978       Impact factor: 12.988

7.  Specificity of rat xenogeneic cell-mediated cytolysis for the products of the K and D loci of the mouse H-2 complex.

Authors:  S J Burakoff; M E Dorf; B Benacerraf
Journal:  J Immunol       Date:  1977-05       Impact factor: 5.422

8.  Absence of H-2 antigens capable of reacting with cytotoxic T cells on a teratoma line expressing a T/t locus antigen.

Authors:  J Forman; E S Vitetta
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

9.  Cells that express viral antigens but lack H-2 determinants are not lysed by immune thymus-derived lymphocytes but are lysed by other antiviral immune attack mechanisms.

Authors:  R M Zinkernagel; M B Oldstone
Journal:  Proc Natl Acad Sci U S A       Date:  1976-10       Impact factor: 11.205

10.  T-cell-mediated cytotoxic immune responses to F9 teratocarcinoma cells: cytolytic effector T cells lyse H-2-negative F9 cells and syngeneic spermatogonia.

Authors:  H Wagner; A Starzinski-Powitz; M Röllinghoff; P Golstein; H Jakob
Journal:  J Exp Med       Date:  1978-01-01       Impact factor: 14.307
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