Yin Guo1, Lijuan Liu2, Deqiang Zheng3,4, Jiali Duan5, Youxin Wang3,4, Jost B Jonas6, Feifei Tian3,4, Shuo Wang3,4, Yujian Sang3,4, Xiaoyu Zhang3,4, Weijie Cao3,4, Jinxia Zhang3,4, Ming Sun3,4, Qiuyue Tian3,4, Xiaoni Meng3,4, Xiuhua Guo3,4, Lijuan Wu3,4. 1. Tongren Eye Care Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 2. Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 3. Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, China. 4. Municipal Key Laboratory of Clinical Epidemiology, Beijing, China. 5. Beijing Center for Disease Prevention and Control, Beijing, China. 6. Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany.
Abstract
Purpose: To determine the prevalence of fundus tessellation and associations with ocular and systemic parameters among junior students from Greater Beijing. Methods: The school-based study included 1443 individuals with a mean age of 12.4 ± 0.5 years (range: 9-16 years). All participants underwent a comprehensive ophthalmic examination and an interview. Fundus tessellation, defined as variation in the visibility of large choroidal vessels, was differentiated into three grades. Results: The prevalence and degree of fundus tessellation were 688/1430 (48.1%; 95% confidence intervals [CI]: 45.5%, 50.7%) and 0.54 ± 0.61 (median, 0.00; range, 0-3), respectively. In multivariable regression analysis, a higher degree of fundus tessellation was associated with reduced subfoveal choroidal thickness (P < 0.001; beta, -0.02; odds ratio [OR], 0.98; 95% CI: 0.98, 0.99) and longer axial length (P < 0.001; beta, 0.23; OR, 1.25; 95% CI: 1.10, 1.43). Subfoveal choroidal thickness decreased from 299 ± 61 μm (95% CI: 293, 304) in eyes without fundus tessellation to 246 ± 57 μm (95% CI: 241, 251), 197 ± 43 μm (95% CI: 187, 207), and 131 ± 30 μm (95% CI: 93, 168) in eyes with grade 1, 2, and 3 fundus tessellation, respectively. A higher degree of peripapillary fundus tessellation was associated with reduced subfoveal choroidal thickness (P < 0.001; beta, -0.02; OR, 0.98; 95% CI: 0.98, 0.99) and younger age at myopia onset (P = 0.008; beta, 0.41; OR, 1.51; 95% CI: 1.11, 2.04). Conclusions: The prevalence of fundus tessellation is relatively high in Chinese teenagers. As in adults, the degree of fundus tessellation is a surrogate for choroidal thickness in teenagers. Marked fundus tessellation indicates a leptochoroid and is associated with earlier myopia onset.
Purpose: To determine the prevalence of fundus tessellation and associations with ocular and systemic parameters among junior students from Greater Beijing. Methods: The school-based study included 1443 individuals with a mean age of 12.4 ± 0.5 years (range: 9-16 years). All participants underwent a comprehensive ophthalmic examination and an interview. Fundus tessellation, defined as variation in the visibility of large choroidal vessels, was differentiated into three grades. Results: The prevalence and degree of fundus tessellation were 688/1430 (48.1%; 95% confidence intervals [CI]: 45.5%, 50.7%) and 0.54 ± 0.61 (median, 0.00; range, 0-3), respectively. In multivariable regression analysis, a higher degree of fundus tessellation was associated with reduced subfoveal choroidal thickness (P < 0.001; beta, -0.02; odds ratio [OR], 0.98; 95% CI: 0.98, 0.99) and longer axial length (P < 0.001; beta, 0.23; OR, 1.25; 95% CI: 1.10, 1.43). Subfoveal choroidal thickness decreased from 299 ± 61 μm (95% CI: 293, 304) in eyes without fundus tessellation to 246 ± 57 μm (95% CI: 241, 251), 197 ± 43 μm (95% CI: 187, 207), and 131 ± 30 μm (95% CI: 93, 168) in eyes with grade 1, 2, and 3 fundus tessellation, respectively. A higher degree of peripapillary fundus tessellation was associated with reduced subfoveal choroidal thickness (P < 0.001; beta, -0.02; OR, 0.98; 95% CI: 0.98, 0.99) and younger age at myopia onset (P = 0.008; beta, 0.41; OR, 1.51; 95% CI: 1.11, 2.04). Conclusions: The prevalence of fundus tessellation is relatively high in Chinese teenagers. As in adults, the degree of fundus tessellation is a surrogate for choroidal thickness in teenagers. Marked fundus tessellation indicates a leptochoroid and is associated with earlier myopia onset.
Authors: Lei Shao; Xiaomei Zhang; Teng Hu; Yang Chen; Chuan Zhang; Li Dong; Saiguang Ling; Zhou Dong; Wen Da Zhou; Rui Heng Zhang; Lei Qin; Wen Bin Wei Journal: Front Med (Lausanne) Date: 2022-03-10