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Literature DB >> 3156049

Inhibition of hepatocyte plasma membrane Ca2+-ATPase activity by menadione metabolism and its restoration by thiols.

P Nicotera, M Moore, F Mirabelli, G Bellomo, S Orrenius.

Abstract

Incubation of isolated rat hepatocytes with cytotoxic concentrations of menadione resulted in inhibition of plasma membrane Ca2+-ATPase activity. This could be restored by subsequent treatment with either dithiothreitol or reduced glutathione, suggesting that the inhibition by menadione was due to oxidation of sulfhydryl groups critical for Ca2+-ATPase activity.

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Year: 1985 PMID： 3156049 DOI： 10.1016/0014-5793(85)81131-5

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

12 in total

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Authors: M Floreani; E Santi Soncin; F Carpenedo
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Review 3. Physiological roles of nicotinamide nucleotide transhydrogenase.

Authors: J B Hoek; J Rydström
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4. Oxidative Signals in Tobacco Increase Cytosolic Calcium.

Authors: A. H. Price; A. Taylor; S. J. Ripley; A. Griffiths; A. J. Trewavas; M. R. Knight
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5. Oxidative damage to sarcoplasmic reticulum Ca(2+)-pump induced by Fe2+/H2O2/ascorbate is not mediated by lipid peroxidation or thiol oxidation and leads to protein fragmentation.

Authors: R F Castilho; P C Carvalho-Alves; A E Vercesi; S T Ferreira
Journal: Mol Cell Biochem Date: 1996-06-21 Impact factor: 3.396

Inhibition of hepatocyte plasma membrane Ca2+-ATPase activity by menadione metabolism and its restoration by thiols.

Review 1. Oxidative stress and living cells.

2. Effects of 2-methyl-1,4-naphthoquinone (menadione) on myocardial contractility and cardiac sarcoplasmic reticulum Ca-ATPase.

Review 3. Physiological roles of nicotinamide nucleotide transhydrogenase.

4. Oxidative Signals in Tobacco Increase Cytosolic Calcium.

5. Oxidative damage to sarcoplasmic reticulum Ca(2+)-pump induced by Fe2+/H2O2/ascorbate is not mediated by lipid peroxidation or thiol oxidation and leads to protein fragmentation.

6. Cytotoxicity of propyl gallate and related compounds in rat hepatocytes.

7. Effect of antihepatotoxic agents against microcystin-LR toxicity in cultured rat hepatocytes.

8. Plasma-membrane calcium-pump isoforms in human and rat liver.

9. Cytosolic calcium increase in coronary endothelial cells after H2O2 exposure and the inhibitory effect of U78517F.

Review 10. Mechanisms of cell injury by activated oxygen species.