| Literature DB >> 31558788 |
Thomas Luft1, Axel Benner2, Tobias Terzer2, Sonata Jodele3, Christopher E Dandoy3, Rainer Storb4,5, Lambros Kordelas6, Dietrich Beelen6, Ted Gooley4,5, Brenda M Sandmaier4,5, Mohamed Sorror4,5, Markus Zeisbrich7, Aleksandar Radujkovic8, Peter Dreger8, Olaf Penack9,10,11.
Abstract
Allogeneic stem cell transplantation (alloSCT) is an effective immunotherapy in patients with hematological malignancies. Endothelial dysfunction was linked to major complications after alloSCT. We asked the question if the "Endothelial Activation and Stress Index" (EASIX; [(creatinine × LDH) ÷ thrombocytes]) can predict mortality after alloSCT. We performed a retrospective cohort analysis in five alloSCT centers in the USA and Germany. EASIX was assessed prior to conditioning (EASIX-pre) and correlated with mortality in 755 patients of a training cohort in multivariable models. The predictive model established in the training cohort was validated in 1267 adult allo-recipients. Increasing EASIX-pre predicted lower overall survival (OS) after alloSCT, and successful model validation was achieved for the validation cohort. We found that EASIX-pre predicts OS irrespective of established scores. Moreover, EASIX-pre was also a significant prognostic factor for transplant-associated microangiopathy. Finally, EASIX-pre correlated with biomarkers of endothelial homeostasis such as CXCL8, interleukin-18, and insulin-like-growth-factor-1 serum levels. This study establishes EASIX-pre based on a standard laboratory biomarker panel as a predictor of individual risk of mortality after alloSCT independently from established clinical criteria.Entities:
Year: 2019 PMID： 31558788 DOI： 10.1038/s41409-019-0703-1
Source DB: PubMed Journal: Bone Marrow Transplant ISSN： 0268-3369 Impact factor: 5.483