Simone Biscaglia1, Gianluca Campo1,2, Emmanuel Sorbets3,4,5, Ian Ford6, Kim M Fox5, Nicola Greenlaw6, Alexander Parkhomenko7, Jean-Claude Tardif8, Luigi Tavazzi2, Michal Tendera9, Kirsty Wetherall6, Roberto Ferrari1,2, Ph Gabriel Steg4,5,10. 1. Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona (FE), Italy. 2. Maria Cecilia Hospital, GVM Care and Research, Cotignola, Italy. 3. Hôpital Avicenne, Assistance Publique Hôpitaux de Paris & Université Paris 13, Bobigny, France. 4. FACT (French Alliance for Cardiovascular Trials), INSERM U1148, Paris, France. 5. National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, London, UK. 6. University of Glasgow, UK. 7. Institute of Cardiology, Kiev, Ukraine. 8. Montreal Heart Institute, Université de Montreal, Canada. 9. Medical University of Silesia, School of Medicine in Katowice, Department of Cardiology and Structural Heart Disease, Poland. 10. Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris and Université de Paris, France.
Abstract
AIMS: The aims of this study were to ascertain the relationship between level of physical activity and outcomes and to discriminate the determinants of physical activity performance or avoidance. METHODS: CLARIFY is an international prospective registry of 32,370 consecutive outpatients with stable coronary artery disease who were followed for up to five years. Patients were grouped according to the level and frequency of physical activity: i) sedentary (n = 5223; 16.1%); ii) only light physical activity most weeks (light; n = 16,634; 51.4%); iii) vigorous physical activity once or twice per week (vigorous ≤ 2×; n = 5427; 16.8%); iv) vigorous physical activity three or more times per week (vigorous >2×; n = 5086; 15.7%). The primary outcome was the composite of cardiovascular death, myocardial infarction and stroke. RESULTS: Patients performing vigorous physical activity ≤2 × had the lowest risk of the primary outcome (hazard ratio, 0.82; 95% confidence interval, 0.71-0.93; p = 0.0031) taking the light group as reference. Engaging in more frequent exercise did not result in further outcome benefit. All-cause death, cardiovascular death, and stroke occurred less frequently in patients performing vigorous physical activity ≤2×. However, the rate of myocardial infarction was comparable between the four physical activity groups. Female sex, peripheral artery disease, diabetes, previous myocardial infarction or stroke, pulmonary disease and body mass index all emerged as independent predictors of lower physical activity. CONCLUSION: Vigorous physical activity once or twice per week was associated with superior cardiac outcomes compared with patients performing no or a low level of physical activity in outpatients with stable coronary artery disease.
AIMS: The aims of this study were to ascertain the relationship between level of physical activity and outcomes and to discriminate the determinants of physical activity performance or avoidance. METHODS: CLARIFY is an international prospective registry of 32,370 consecutive outpatients with stable coronary artery disease who were followed for up to five years. Patients were grouped according to the level and frequency of physical activity: i) sedentary (n = 5223; 16.1%); ii) only light physical activity most weeks (light; n = 16,634; 51.4%); iii) vigorous physical activity once or twice per week (vigorous ≤ 2×; n = 5427; 16.8%); iv) vigorous physical activity three or more times per week (vigorous >2×; n = 5086; 15.7%). The primary outcome was the composite of cardiovascular death, myocardial infarction and stroke. RESULTS:Patients performing vigorous physical activity ≤2 × had the lowest risk of the primary outcome (hazard ratio, 0.82; 95% confidence interval, 0.71-0.93; p = 0.0031) taking the light group as reference. Engaging in more frequent exercise did not result in further outcome benefit. All-cause death, cardiovascular death, and stroke occurred less frequently in patients performing vigorous physical activity ≤2×. However, the rate of myocardial infarction was comparable between the four physical activity groups. Female sex, peripheral artery disease, diabetes, previous myocardial infarction or stroke, pulmonary disease and body mass index all emerged as independent predictors of lower physical activity. CONCLUSION: Vigorous physical activity once or twice per week was associated with superior cardiac outcomes compared with patients performing no or a low level of physical activity in outpatients with stable coronary artery disease.
Authors: Bram M A van Bakel; Esmée A Bakker; Femke de Vries; Dick H J Thijssen; Thijs M H Eijsvogels Journal: Int J Environ Res Public Health Date: 2021-11-13 Impact factor: 4.614
Authors: Elisabetta Tonet; Albert Ariza-Solé; Matteo Serenelli; Francesc Formiga; Juan Sanchis; Rita Pavasini; Pablo Diez-Villanueva; Francesco Vitali; Clara Bonanad; Giovanni Grazzi; Antoni Carol; Giorgio Chiaranda; Graziella Pompei; Laura Sofia Cardelli; Serena Caglioni; Federico Gibiino; Stefano Volpato; Gianluca Campo Journal: BMC Med Date: 2022-01-20 Impact factor: 8.775