Cédric Dananché1,2, Gláucia Paranhos-Baccalà1, Mélina Messaoudi1, Mariam Sylla3, Shally Awasthi4, Ashish Bavdekar5, Sonali Sanghavi5, Souleymane Diallo3, Jean-William Pape6, Vanessa Rouzier6, Monidarin Chou7, Tekchheng Eap7, Mala Rakoto-Andrianarivelo8, Muriel Maeder8, Jianwei Wang9, Lili Ren9, Budragchaagiin Dash-Yandag10, Pagbajabyn Nymadawa10, Rosa Guillen11, Graciela Russomando11, Hubert Endtz1, Florence Komurian-Pradel1, Philippe Vanhems1,2, Valentina Sánchez Picot1. 1. Emerging Pathogens Laboratory, Fondation Mérieux, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale (INSERM) U1111, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR)5308, École Nationale Supérieure (ENS) de Lyon, Université Claude Bernard Lyon, France. 2. Infection Control and Epidemiology Department, Hospices Civils de Lyon, France. 3. Gabriel Touré Hospital, Bamako, Mali. 4. Chatrapati Shahu Ji Maharaj Medical University, Lucknow, India. 5. KEM Hospital Research Center, Pune, India. 6. Centres Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes, Port-au-Prince, Haiti. 7. Faculty of Pharmacy, University of Health Sciences, Phnom Penh, Cambodia. 8. Fondation Mérieux, Centre d'Infectiologie Charles Mérieux, Antananarivo, Madagascar. 9. Ministry of Health Key Laboratory of the Systems Biology of Pathogens and Dr. Christophe Mérieux Laboratory, Fondation Mérieux, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 10. Mongolian Academy of Medical Sciences, Ulaanbaatar. 11. Research Institute of Health, Asuncion, Paraguay.
Abstract
BACKGROUND: Improving knowledge regarding Streptococcus pneumoniae distribution in pneumonia cases is important to better target preventive and curative measures. The objective was to describe S. pneumoniae serotypes in children with or without pneumonia. METHODS: It was a case-control study carried out in 8 developing and emerging countries between 2010 and 2014. Cases were children aged <5 years admitted to the hospital for pneumonia. Controls were children admitted for surgery or routine outpatient care. RESULTS: In nasopharyngeal samples, S. pneumoniae were detected in 68.2% of the cases and 47.5% of the controls (P < .001). Nasopharyngeal carriage was associated with a higher risk of being a case in 6/8 study sites (adjusted odds ratio ranged from 0.71 [95% confidence interval [CI], .39-1.29; P = .26] in India [Pune/Vadu] to 11.86 [95% CI, 5.77-24.41; P < .001] in Mongolia). The 13-valent pneumococcal conjugate vaccine (PCV13) serotypes were more frequently detected in cases with nasopharyngeal carriage (67.1%) than in controls with nasopharyngeal carriage (54.6%), P < .001. Streptococcus pneumoniae was detected in blood by polymerase chain reaction in 8.3% of the cases. Of 34 cases with an S. pneumoniae serotype detected in blood, 27 (79%) had the same serotype in the nasopharyngeal sample. CONCLUSIONS: The results confirm the assumption that the isolate carrying or causing disease in an individual is of the same serotype. Most serotypes independently associated with nasopharyngeal carriage or pneumonia are covered by PCV13, suggesting that increased PCV coverage would reduce the burden of S. pneumoniae-related pneumonia.
BACKGROUND: Improving knowledge regarding Streptococcus pneumoniae distribution in pneumonia cases is important to better target preventive and curative measures. The objective was to describe S. pneumoniae serotypes in children with or without pneumonia. METHODS: It was a case-control study carried out in 8 developing and emerging countries between 2010 and 2014. Cases were children aged <5 years admitted to the hospital for pneumonia. Controls were children admitted for surgery or routine outpatient care. RESULTS: In nasopharyngeal samples, S. pneumoniae were detected in 68.2% of the cases and 47.5% of the controls (P < .001). Nasopharyngeal carriage was associated with a higher risk of being a case in 6/8 study sites (adjusted odds ratio ranged from 0.71 [95% confidence interval [CI], .39-1.29; P = .26] in India [Pune/Vadu] to 11.86 [95% CI, 5.77-24.41; P < .001] in Mongolia). The 13-valent pneumococcal conjugate vaccine (PCV13) serotypes were more frequently detected in cases with nasopharyngeal carriage (67.1%) than in controls with nasopharyngeal carriage (54.6%), P < .001. Streptococcus pneumoniae was detected in blood by polymerase chain reaction in 8.3% of the cases. Of 34 cases with an S. pneumoniae serotype detected in blood, 27 (79%) had the same serotype in the nasopharyngeal sample. CONCLUSIONS: The results confirm the assumption that the isolate carrying or causing disease in an individual is of the same serotype. Most serotypes independently associated with nasopharyngeal carriage or pneumonia are covered by PCV13, suggesting that increased PCV coverage would reduce the burden of S. pneumoniae-related pneumonia.
Authors: Jorge E Vidal; Meagan N Wier; Uriel A Angulo-Zamudio; Erin McDevitt; Ana G Jop Vidal; Babek Alibayov; Anna Scasny; Sandy M Wong; Brian J Akerley; Larry S McDaniel Journal: Infect Immun Date: 2021-09-20 Impact factor: 3.441
Authors: Louise K Francois Watkins; Jennifer L Milucky; Lesley McGee; Florence Siné St-Surin; Pengbo Liu; Theresa Tran; Sopio Chochua; Gerard Joseph; Nong Shang; Stanley Juin; Patrick Dely; Roopal Patel; Chris A Van Beneden Journal: J Infect Dis Date: 2021-09-01 Impact factor: 7.759
Authors: Eileen M Dunne; Yinglei Hua; Rasheed Salaudeen; Ilias Hossain; Malick Ndiaye; Belinda D Ortika; E Kim Mulholland; Jason Hinds; Sam Manna; Grant A Mackenzie; Catherine Satzke Journal: J Infect Dis Date: 2022-04-19 Impact factor: 7.759