| Literature DB >> 31556857 |
Deepika Sharma1, Gopal Singh Bisht2.
Abstract
The current trend of increment in the frequency of antifungal resistance has brought research into an era where new antifungal compounds with novel mechanisms of action are required. Natural antimicrobial peptides, which are ubiquitous components of innate immunity, represent their candidature for novel antifungal peptides. Various antifungal peptides have been isolated from different species ranging from small marine organisms to insects and from various other living species. Based on these peptides, various mimetics of antifungal peptides have also been synthesized using non-natural amino acids. Utilization of these antifungal peptides is somehow limited due to their toxic and unstable nature. This review discusses recent updates and future directions of antifungal peptides, for taking them to the shelf from the bench. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Keywords: Antifungal peptides; antimicrobial peptides; fungal infections; living species; marine organisms; microbial resistance.
Year: 2020 PMID: 31556857 DOI: 10.2174/1389557519666190926112423
Source DB: PubMed Journal: Mini Rev Med Chem ISSN: 1389-5575 Impact factor: 3.862