| Literature DB >> 31556612 |
David Huang1, Diego Olivieri1, Yang Sun1, Pengpeng Zhang1, Timothy R Newhouse1.
Abstract
This report demonstrates the possibility of a nickel-catalyzed difunctionalization of unactivated alkenes initiated by an unstabilized enolate nucleophile. The process tolerates a diverse range of electrophiles, including aryl, heteroaryl, alkenyl, and amino electrophiles. An electron-deficient phosphine ligand and a tetrabutylammonium salt additive were crucial for promoting efficient vicinal difunctionalization.Entities:
Year: 2019 PMID： 31556612 DOI： 10.1021/jacs.9b09245
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419