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Literature DB >> 315563

Monoclonal antibody directed to a B-cell antigen present in rats, mice, and humans.

D L Gasser, B A Winters, J B Haas, T J McKearn, R H Kennett.

Abstract

Spleen cells from a LEW.AVN rat immunized with cells from an MNR rat were fused with mouse myeloma cells to produce hybrid cell lines. One of these hybridomas produced a monoclonal antibody that was cytotoxic for bone marrow-derived (B) but not thymus-derived (T) cells. The antigen defined by this antibody is determined by a gene linked to the major histocompatibility complex (MHC). The antigen is also present on B cells of most mouse strains and is determined by an MHC-linked gene in this species as well. In both rats and mice, the gene determining the antigen maps within the immune response region of the MHC. All human B-cell lines, but not T-cell lines, and B but not T cells of all human donors tested so far are also positive for this antigen. Among human-mouse somatic cell lines that have lost various human chromosomes, this B-cell antigen is present on all lines that are positive for HLA antigen but is absent from all lines that have lost HLA.

Entities: Disease Species

Mesh：

Substances：

Year: 1979 PMID： 315563 PMCID： PMC411634 DOI： 10.1073/pnas.76.9.4636

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

16 in total

1. Ia antigens in inbred rats and their relationship to the MLR phenotype.

Authors: S F Radka; D V Cramer; T J Gill
Journal: J Immunol Date: 1977-12 Impact factor: 5.422

2. Phenotypic characterisation of a unique non-T, non-B acute lymphoblastic leukaemia cell line.

Authors: C Rosenfeld; A Goutner; C Choquet; A M Venuat; B Kayibanda; J L Pico; M F Greaves
Journal: Nature Date: 1977-06-30 Impact factor: 49.962

3. Ag-B-linked analogue of Ia antigens in the rat.

Authors: N Shinohara; S E Cullen; D H Sachs
Journal: J Immunol Date: 1977-06 Impact factor: 5.422

4. Demonstration of cell surface antigens and their antibodies by the peroxidase-antiperoxidase method.

Authors: K J Bross; G A Pangalis; C G Staatz; K G Blume
Journal: Transplantation Date: 1978-06 Impact factor: 4.939

5. A recombinant in the major histocompatibility complex of the rat.

Authors: G W Butcher; J C Howard
Journal: Nature Date: 1977-03-24 Impact factor: 49.962

6. Hybrid plasmacytoma production: fusions with adult spleen cells, monoclonal spleen fragments, neonatal spleen cells and human spleen cells.

Authors: R H Kennett; K A Denis; A S Tung; N R Klinman
Journal: Curr Top Microbiol Immunol Date: 1978 Impact factor: 4.291

7. Sharing of Ia antigens between species. II. Molecular localization of shared Ia determinants implies the existence of more than one I sublocus of the rat MHC.

Authors: N Shinohara; J K Lunney; D H Sachs
Journal: J Immunol Date: 1978-08 Impact factor: 5.422

8. Partial N-terminal amino acid sequence of rat transplantation antigens.

Authors: E P Blankenhorn; J M Cecka; D Goetze; L Hood
Journal: Nature Date: 1978-07-06 Impact factor: 49.962

9. The graft-versus-host reactivity in AG-B/MLR disparate strains of rats.

Authors: D V Cramer; B K Davis; J W Shonnard; T J Gill
Journal: Transplantation Date: 1977-06 Impact factor: 4.939

10. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis.

Authors: C J Barnstable; W F Bodmer; G Brown; G Galfre; C Milstein; A F Williams; A Ziegler
Journal: Cell Date: 1978-05 Impact factor: 41.582

9 in total

9. Murine H-2Dd-reactive monoclonal antibodies recognize shared antigenic determinant(s) on human HLA-B7 or HLA-B27 molecules or both.

Authors: N Rebai; P Mercier; T Kristensen; C Devaux; B Malissen; C Mawas; M Pierres
Journal: Immunogenetics Date: 1983 Impact factor: 2.846

9 in total

Monoclonal antibody directed to a B-cell antigen present in rats, mice, and humans.

1. Ia antigens in inbred rats and their relationship to the MLR phenotype.

2. Phenotypic characterisation of a unique non-T, non-B acute lymphoblastic leukaemia cell line.

3. Ag-B-linked analogue of Ia antigens in the rat.

4. Demonstration of cell surface antigens and their antibodies by the peroxidase-antiperoxidase method.

5. A recombinant in the major histocompatibility complex of the rat.

6. Hybrid plasmacytoma production: fusions with adult spleen cells, monoclonal spleen fragments, neonatal spleen cells and human spleen cells.

7. Sharing of Ia antigens between species. II. Molecular localization of shared Ia determinants implies the existence of more than one I sublocus of the rat MHC.

8. Partial N-terminal amino acid sequence of rat transplantation antigens.

9. The graft-versus-host reactivity in AG-B/MLR disparate strains of rats.

10. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis.

Review 1. Hybridomas: a new dimension in biological analyses.

2. Evolution of HLA antigenic determinants: species cross-reactions of monoclonal antibodies.

3. Characterization of RT1gv1: a new rat MHC haplotype isolated from the wild.

Review 4. Monoclonal antibodies as tools in hematology.

5. Enrichment of human marrow lymphocytes with monoclonal antibodies to murine antigens.

6. Monoclonal rat anti-MHC alloantibodies detect HLA-linked polymorphisms in humans.

7. Cell surface properties of HLA antigens on Epstein-Barr virus-transformed cell lines.

8. Genetic control of the expression of class I molecules on rat erythrocytes.

9. Murine H-2Dd-reactive monoclonal antibodies recognize shared antigenic determinant(s) on human HLA-B7 or HLA-B27 molecules or both.