Literature DB >> 31555978

Sex-related differences in olfactory function and evaluation of possible confounding factors among patients with Parkinson's disease.

P Solla1, C Masala2, A Liscia3, R Piras3, T Ercoli4, L Fadda4, T Hummel5, A Haenher5, G Defazio4.   

Abstract

The role of specific sex-related patterns in olfactory dysfunctions of Parkinson's disease (PD) patients is unclear. The aim of this study was to assess the presence of specific sex-related patterns in olfactory dysfunctions excluding the possibility of confounding effects in patients with Parkinson's disease. One hundred and sixty-eight participants (99 PD patients and 69 controls) were enrolled and evaluated using Sniffin' Sticks Extended test (SSET). There was no significant sex difference in the control group for the SSET parameters. By contrast, in the PD group male patients scored significantly lower on odor discrimination (OD), identification (OI), and Threshold-Discrimination-Identification (TDI) score than females. On multivariable linear regression analysis, the only significant predictors of TDI score were sex and apathy. Among PD patients, men showed a significantly greater impairment compared to women in OI, OD and TDI score, but not in odor threshold (OT). These findings highlighted the possible role of sex differences in the development of associated PD non-motor symptoms.

Entities:  

Keywords:  Non-motor symptoms; Olfaction; Parkinson’s disease; Sex differences

Mesh：

Year:  2019        PMID： 31555978     DOI： 10.1007/s00415-019-09551-2

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  40 in total

1.  Psychometric properties of the Starkstein Apathy Scale in patients with early untreated Parkinson disease.

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Journal:  Am J Geriatr Psychiatry       Date:  2012-02       Impact factor: 4.105

2.  Gender-related changes in increase of dopaminergic neurons in the olfactory bulb of Parkinson's disease patients.

Authors:  Evelien Huisman; Harry B M Uylings; Piet V Hoogland
Journal:  Mov Disord       Date:  2008-07-30       Impact factor: 10.338

3.  Correlation among olfactory function, motors' symptoms, cognitive impairment, apathy, and fatigue in patients with Parkinson's disease.

Authors:  Carla Masala; Paolo Solla; A Liscia; G Defazio; L Saba; A Cannas; A Cavazzana; T Hummel; A Haehner
Journal:  J Neurol       Date:  2018-05-26       Impact factor: 4.849

4.  Gender differences in motor and non-motor symptoms among Sardinian patients with Parkinson's disease.

Authors:  Paolo Solla; Antonino Cannas; Federica Carla Ibba; Federico Loi; Marta Corona; Gianni Orofino; Maria Giovanna Marrosu; Francesco Marrosu
Journal:  J Neurol Sci       Date:  2012-08-27       Impact factor: 3.181

Review 5.  The relevance of gender in Parkinson's disease: a review.

Authors:  Marina Picillo; Alessandra Nicoletti; Vincenza Fetoni; Barbara Garavaglia; Paolo Barone; Maria Teresa Pellecchia
Journal:  J Neurol       Date:  2017-01-04       Impact factor: 4.849

6.  Gender differences in Parkinson's disease.

Authors:  Charlotte A Haaxma; Bastiaan R Bloem; George F Borm; Wim J G Oyen; Klaus L Leenders; Silvia Eshuis; Jan Booij; Dean E Dluzen; Martin W I M Horstink
Journal:  J Neurol Neurosurg Psychiatry       Date:  2006-11-10       Impact factor: 10.154

Review 7.  Sex differences and reproductive hormone influences on human odor perception.

Authors:  Richard L Doty; E Leslie Cameron
Journal:  Physiol Behav       Date:  2009-03-09

Review 8.  Olfaction in Parkinson's disease.

Authors:  Richard L Doty
Journal:  Parkinsonism Relat Disord       Date:  2007       Impact factor: 4.891

9.  Gender-related differences in the burden of non-motor symptoms in Parkinson's disease.

Authors:  Pablo Martinez-Martin; Cristian Falup Pecurariu; Per Odin; Jacobus J van Hilten; Angelo Antonini; Jose M Rojo-Abuin; Vanderci Borges; Claudia Trenkwalder; Dag Aarsland; David J Brooks; Kallol Ray Chaudhuri
Journal:  J Neurol       Date:  2012-01-12       Impact factor: 4.849

10.  Olfactory function and the social lives of older adults: a matter of sex.

Authors:  Sanne Boesveldt; Jason R Yee; Martha K McClintock; Johan N Lundström
Journal:  Sci Rep       Date:  2017-03-22       Impact factor: 4.379
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  14 in total

1.  Distribution of α-Synuclein Aggregation in the Peripheral Tissues.

Authors:  Yan-Yan Li; Tian-Tian Zhou; Yi Zhang; Nai-Hong Chen; Yu-He Yuan
Journal:  Neurochem Res       Date:  2022-03-28       Impact factor: 3.996

Review 2.  Systematic review and meta-analysis of Sniffin Sticks Test performance in Parkinson's disease patients in different countries.

Authors:  Sheila Trentin; Bruno Samuel Fraiman de Oliveira; Yuri Ferreira Felloni Borges; Carlos Roberto de Mello Rieder
Journal:  Eur Arch Otorhinolaryngol       Date:  2021-07-28       Impact factor: 2.503

3.  Sex Differences in Patterns of Sleep Disorders Among Hospitalizations With Parkinson's Disease: 2004-2014 Nationwide Inpatient Sample.

Authors:  Hind A Beydoun; Sharmin Hossain; Shuyan Huang; May A Beydoun; Brook T Alemu; Shaker M Eid; Alan B Zonderman
Journal:  Psychosom Med       Date:  2021-06-01       Impact factor: 3.864

4.  Effect of Olfactory and Gustatory Dysfunction and Motor Symptoms on Body Weight in Patients with Parkinson's Disease.

Authors:  Carla Masala; Francesco Loy; Raffaella Piras; Anna Liscia; Laura Fadda; Alan Moat; Paolo Solla; Giovanni Defazio
Journal:  Brain Sci       Date:  2020-04-07

5.  Rasagiline Withdrawal Syndrome in Parkinson's Disease.

Authors:  Paolo Solla; Tommaso Ercoli; Carla Masala; Gianni Orofino; Laura Fadda; Davide Giacomo Corda; Ignazio Roberto Zarbo; Mario Meloni; Elia Sechi; Caterina Francesca Bagella; Giovanni Defazio
Journal:  Brain Sci       Date:  2022-02-05

6.  Sex-Related Longitudinal Change of Motor, Non-Motor, and Biological Features in Early Parkinson's Disease.

Authors:  Marina Picillo; David-Erick LaFontant; Susan Bressman; Chelsea Caspell-Garcia; Christopher Coffey; Hyunkeun Ryan Cho; Elliot L Burghardt; Nabila Dahodwala; Rachel Saunders-Pullman; Caroline M Tanner; Amy W Amara
Journal:  J Parkinsons Dis       Date:  2022       Impact factor: 5.520

7.  Correlation between olfactory function, age, sex, and cognitive reserve index in the Italian population.

Authors:  Carla Masala; Annachiara Cavazzana; Fabrizio Sanna; Maria Paola Cecchini; Alice Zanini; Flavia Gasperi; Leonardo Menghi; Isabella Endrizzi; Monica Borgogno; Serena Drago; Elena Cantone; Andrea Ciofalo; Alberto Macchi; Giulia Monti; Valentina Parma; Maria Piochi; Ilenia Pinna; Luisa Torri; Giorgia Cabrino; Giancarlo Ottaviano; Alfonso Luca Pendolino; Angela Pignatelli; Faride Pighin; Vincenzo Bochicchio; Gaetano Motta; Giorgia Fontana; Benedetta Pasquariello; Carlo Cavaliere; Valentina Iacono; Thomas Hummel
Journal:  Eur Arch Otorhinolaryngol       Date:  2022-02-24       Impact factor: 3.236

8.  Olfactory Impairment in Parkinson's Disease Patients with Tremor Dominant Subtype Compared to Those with Akinetic Rigid Dominant Subtype: A Pilot Study.

Authors:  Paolo Solla; Carla Masala; Tommaso Ercoli; Gianni Orofino; Francesco Loy; Ilenia Pinna; Laura Fadda; Giovanni Defazio
Journal:  Brain Sci       Date:  2022-01-31

9.  Age-Related Cognitive Decline and the Olfactory Identification Deficit Are Associated to Increased Level of Depression.

Authors:  Fabrizio Sanna; Francesco Loy; Raffaella Piras; Alan Moat; Carla Masala
Journal:  Front Neurosci       Date:  2021-02-22       Impact factor: 4.677

10.  Frequency and Determinants of Olfactory Hallucinations in Parkinson's Disease Patients.

Authors:  Paolo Solla; Carla Masala; Ilenia Pinna; Tommaso Ercoli; Francesco Loy; Gianni Orofino; Laura Fadda; Giovanni Defazio
Journal:  Brain Sci       Date:  2021-06-24
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