| Literature DB >> 31551023 |
Wan N A D Hishamnuri1,2,3, Shotaro Nakagun1,2,3, Masaki Maezawa1,2,3, Kana Sakaguchi1,2,3, Nao Akiyama1,2,3, Ken-Ichi Watanabe1,2,3, Noriyuki Horiuchi1,2,3, Yoshiyasu Kobayashi1,2,3, Hisashi Inokuma1,2,3.
Abstract
A 19-mo-old Holstein heifer was inactive and dyspneic. Physical examination revealed wheezing, exophthalmos, a cervical mass, and lymphadenopathy. Cytology of the cervical mass and lymph nodes showed predominantly large atypical lymphocytes. Lactate dehydrogenase and thymidine kinase activities were elevated. Although nested PCR for bovine leukemia virus (BLV) using blood was positive, quantitative PCR showed a low number of provirus copies. Autopsy revealed enlargement of most lymph nodes examined, as well as white masses of various sizes in muscles of the left hindlimb and thoracic and abdominal organs. Histopathology revealed severe infiltration with neoplastic lymphocytes in these organs. The cervical mass was immune-positive for B-cell markers. The final diagnosis was thymic B-cell lymphoma with BLV infection.Entities:
Keywords: B-cell; bovine leukemia virus; cattle; thymic lymphoma
Mesh：
Year: 2019 PMID： 31551023 PMCID： PMC6900721 DOI： 10.1177/1040638719875501
Source DB: PubMed Journal: J Vet Diagn Invest ISSN： 1040-6387 Impact factor: 1.279