Massimiliano Buoli1, Bruno Mario Cesana2, Giuseppe Maina3, Andreas Conca4, Andrea Fagiolini5, Luca Steardo6, A Carlo Altamura7, Bernardo Dell'Osso8. 1. Department of Psychiatry, University of Milan, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, Italy. Electronic address: massimiliano.buoli@unimi.it. 2. Department of Clinical Sciences and Community Health, Unit of Medical Statistics, Biometry and Bioinformatics "Giulio A. Maccacaro", Faculty of Medicine and Surgery, University of Milan, Milan, Italy. 3. Department of Mental Health, "San Luigi-Gonzaga" Hospital, University of Turin, Orbassano, Turin, Italy. 4. Department of Psychiatry, Bolzano, Italy. 5. Department of Mental Health and Department of Molecular Medicine, University of Siena Medical Center, Siena, Italy. 6. Psychiatric Unit, Department of Health Sciences, University Magna Graecia, Catanzaro, Italy. 7. Department of Psychiatry, University of Milan, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, Italy. 8. Department of Biomedical and Clinical Sciences "Luigi Sacco", Psychiatry Unit 2, ASST-Fatebenefratelli-Sacco, via G.B.Grassi 74, 20157 Milan, Italy; Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA; CRC "Aldo Ravelli" for Neurotechnology and Experimental Brain Therapeutics, University of Milan, Italy.
Abstract
BACKGROUND: we aimed to compare socio-demographic and clinical differences between patients with versus without current RC in order to detect clinical factors that may favor early diagnosis and personalized treatment. METHODS: A total of 1675 patients (males: n = 714 and females: n = 961; bipolar 1: n = 1042 and bipolar 2: n = 633) from different psychiatric clinics were grouped and compared according to the current presence of RC in terms of socio-demographic and clinical variables. Chi-squared tests for qualitative variables and Student's t tests for quantitative variables were executed for group comparison, and multivariable logistic regressions were performed, considering the current presence of RC as dependent variable, and socio-demographic/clinical factors as independent variables. RESULTS: Female gender (male versus female: OR = 0.64, p = 0.04), unidentifiable prevalent polarity (versus depressive polarity: OR = 1.76, p = 0.02; versus manic polarity: OR: 2.86, p < 0.01) and hospitalization in the last year (no versus yes: OR = 0.63, p = 0.02) were found to be associated with RC in the final multivariable regression analysis. CONCLUSIONS: RC in BD seems to be more prevalent in female gender and associated with some unfavorable clinical features, such as an increased risk of hospitalization. These aspects should be taken into account in the management and monitoring of RC versus non-RC patients.
BACKGROUND: we aimed to compare socio-demographic and clinical differences between patients with versus without current RC in order to detect clinical factors that may favor early diagnosis and personalized treatment. METHODS: A total of 1675 patients (males: n = 714 and females: n = 961; bipolar 1: n = 1042 and bipolar 2: n = 633) from different psychiatric clinics were grouped and compared according to the current presence of RC in terms of socio-demographic and clinical variables. Chi-squared tests for qualitative variables and Student's t tests for quantitative variables were executed for group comparison, and multivariable logistic regressions were performed, considering the current presence of RC as dependent variable, and socio-demographic/clinical factors as independent variables. RESULTS: Female gender (male versus female: OR = 0.64, p = 0.04), unidentifiable prevalent polarity (versus depressive polarity: OR = 1.76, p = 0.02; versus manic polarity: OR: 2.86, p < 0.01) and hospitalization in the last year (no versus yes: OR = 0.63, p = 0.02) were found to be associated with RC in the final multivariable regression analysis. CONCLUSIONS: RC in BD seems to be more prevalent in female gender and associated with some unfavorable clinical features, such as an increased risk of hospitalization. These aspects should be taken into account in the management and monitoring of RC versus non-RC patients.
Authors: Massimiliano Buoli; Bruno Mario Cesana; Simone Bolognesi; Andrea Fagiolini; Umberto Albert; Gabriele Di Salvo; Giuseppe Maina; Andrea de Bartolomeis; Maurizio Pompili; Claudia Palumbo; Emi Bondi; Luca Steardo; Pasquale De Fazio; Mario Amore; Mario Altamura; Antonello Bellomo; Alessandro Bertolino; Marco Di Nicola; Guido Di Sciascio; Andrea Fiorillo; Emilio Sacchetti; Gabriele Sani; Alberto Siracusano; Giorgio Di Lorenzo; Alfonso Tortorella; A Carlo Altamura; Bernardo Dell'Osso Journal: Eur Arch Psychiatry Clin Neurosci Date: 2021-10-15 Impact factor: 5.270