Literature DB >> 31550420

The unique moral permissibility of uncontrolled lung donation after circulatory death.

Brendan Parent1, Arthur Caplan1, Luis Angel2, Zachary Kon2, Nancy Dubler1, Lewis Goldfrank3, Jacob Lindner1,4, Stephen P Wall3,5.   

Abstract

Implementing uncontrolled donation after circulatory determination of death (uDCDD) in the United States could markedly improve supply of donor lungs for patients in need of transplants. Evidence from US pilot programs suggests families support uDCDD, but only if they are asked permission for using invasive organ preservation procedures prior to initiation. However, non-invasive strategies that confine oxygenation to lungs may be applicable to the overwhelming majority of potential uDCDD donors that have airway devices in place as part of standard resuscitation. We propose an ethical framework for lung uDCDD by: (a) initiating post mortem preservation without requiring prior permission to protect the opportunity for donation until an authorized party can be found; (b) using non-invasive strategies that confine oxygenation to lungs; and (c) maintaining strict separation between the healthcare team and the organ preservation team. Attempting uDCDD in this way has great potential to obtain more transplantable lungs while respecting donor autonomy and family wishes, securing public support, and enabling authorized persons to affirm or cease preservation decisions without requiring evidence of prior organ donation intent. It ensures prioritization of life-saving, the opportunity to allow willing donors to donate, and respect for bodily integrity while adhering to current ethical norms.
© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.

Entities:  

Keywords:  donors and donation: donation after circulatory death (DCD); donors and donation: extended criteria; editorial/personal viewpoint; ethics and public policy; lung transplantation/pulmonology; organ procurement; organ procurement and allocation

Mesh:

Year:  2019        PMID: 31550420      PMCID: PMC6984986          DOI: 10.1111/ajt.15603

Source DB:  PubMed          Journal:  Am J Transplant        ISSN: 1600-6135            Impact factor:   8.086


  29 in total

1.  2009 global data in organ donation and transplantation: activities, laws, and organization.

Authors:  Beatriz Mahillo; Mar Carmona; Marina Álvarez; Sarah White; Luc Noel; Rafael Matesanz
Journal:  Transplantation       Date:  2011-11-27       Impact factor: 4.939

2.  Expanding the horizons: Uncontrolled donors after circulatory death for lung transplantation-First comparison with brain death donors.

Authors:  Daniel Valdivia; David Gómez de Antonio; Lucas Hoyos; Jose Luis Campo-Cañaveral de la Cruz; Alejandra Romero; Andrés Varela de Ugarte
Journal:  Clin Transplant       Date:  2019-05-07       Impact factor: 2.863

3.  Derivation of the uncontrolled donation after circulatory determination of death protocol for New York city.

Authors:  S P Wall; B J Kaufman; A J Gilbert; Y Yushkov; M Goldstein; J E Rivera; D O'Hara; H Lerner; M Sabeta; M Torres; C L Smith; Z Hedrington; F Selck; K G Munjal; M Machado; S Montella; M Pressman; L W Teperman; N N Dubler; L R Goldfrank
Journal:  Am J Transplant       Date:  2011-06-28       Impact factor: 8.086

4.  Assessment of Lungs for Transplant Recovered from Uncontrolled Donation after Circulatory Determination of Death Donors.

Authors:  Thomas Egan; John Blackwell; Katherine Birchard; Benjamin Haithcock; Jason Long; Stephen Gazda; Nissa Casey; Caitlin Thys
Journal:  Ann Am Thorac Soc       Date:  2017-09

5.  Circulatory death determination in uncontrolled organ donors: a panel viewpoint.

Authors:  James L Bernat; Thomas P Bleck; Sandralee A Blosser; Susan L Bratton; Alexander M Capron; Danielle Cornell; Michael A DeVita; Gerard J Fulda; Alexandra K Glazier; Cynthia J Gries; Mudit Mathur; Thomas A Nakagawa; Sam D Shemie
Journal:  Ann Emerg Med       Date:  2013-06-21       Impact factor: 5.721

Review 6.  Uncontrolled donation after circulatory death: ethics of implementation.

Authors:  María Molina; Beatriz Domínguez-Gil; José M Pérez-Villares; Amado Andrés
Journal:  Curr Opin Organ Transplant       Date:  2019-06       Impact factor: 2.640

7.  Transplantation of lungs from non-heart-beating donors after functional assessment ex vivo.

Authors:  Stig Steen; Qiuming Liao; Per N Wierup; Ramunas Bolys; Leif Pierre; Trygve Sjöberg
Journal:  Ann Thorac Surg       Date:  2003-07       Impact factor: 4.330

8.  Experience With a New Process - Condition T - for Uncontrolled Donation After Circulatory Determination of Death in a University Emergency Department.

Authors:  Michael A DeVita; Clifton W Callaway; Charissa Pacella; Maria Mori Brooks; John Lutz; Susan Stuart
Journal:  Prog Transplant       Date:  2016-03       Impact factor: 1.187

9.  International Society for Heart and Lung Transplantation Donation After Circulatory Death Registry Report.

Authors:  Marcelo Cypel; Bronwyn Levvey; Dirk Van Raemdonck; Michiel Erasmus; John Dark; Robert Love; David Mason; Allan R Glanville; Daniel Chambers; Leah B Edwards; Josef Stehlik; Marshall Hertz; Brian A Whitson; Roger D Yusen; Varun Puri; Peter Hopkins; Greg Snell; Shaf Keshavjee
Journal:  J Heart Lung Transplant       Date:  2015-09-03       Impact factor: 10.247

10.  Successful Transplantation of Lungs From an Uncontrolled Donor After Circulatory Death Preserved In Situ by Alveolar Recruitment Maneuvers and Assessed by Ex Vivo Lung Perfusion.

Authors:  F Valenza; G Citerio; A Palleschi; A Vargiolu; B Safaee Fakhr; A Confalonieri; M Nosotti; S Gatti; S Ravasi; S Vesconi; A Pesenti; F Blasi; L Santambrogio; L Gattinoni
Journal:  Am J Transplant       Date:  2016-01-30       Impact factor: 8.086

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  1 in total

Review 1.  Donation after circulatory death donors in lung transplantation.

Authors:  Thomas M Egan; Benjamin E Haithcock; Jason Lobo; Gita Mody; Robert B Love; John Jacob Requard; John Espey; Mir Hasnain Ali
Journal:  J Thorac Dis       Date:  2021-11       Impact factor: 3.005

  1 in total

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