Anahita Bassir Nia1, Claire Mann2, Harsimar Kaur3, Mohini Ranganathan4. 1. Yale University School of Medicine, New Haven, Connecticut. 2. Icahn School of Medicine at Mount Sinai, New York City, New York. 3. Yale University School of Medicine. 4. Yale University School of Medicine, VA Connecticut Healthcare System.
Abstract
PURPOSE OF REVIEW: To summarize the current literature on the effects of cannabinoids in humans and to discuss the existing literature on the sex- and gender-related differences in the effects of cannabinoids. RECENT FINDINGS: Cannabis and its constituent cannabinoids are associated with risk of addiction, cognitive deficits and mood/psychotic disorders. Preclinical and emerging clinical data suggest greater sensitivity to the effects of cannabinoids in women. SUMMARY: Cannabis is one of the most commonly used drugs with increasing rates of use. Women in particular may be at a greater risk of adverse outcomes given the previously described "telescoping effect" of substance use in women. Human data examining the sex- and gender-related differences in the effects of cannabinoids and factors underlying these differences are very limited. This represents a critical gap in the literature and needs to be systematically examined in future studies.
PURPOSE OF REVIEW: To summarize the current literature on the effects of cannabinoids in humans and to discuss the existing literature on the sex- and gender-related differences in the effects of cannabinoids. RECENT FINDINGS: Cannabis and its constituent cannabinoids are associated with risk of addiction, cognitive deficits and mood/psychotic disorders. Preclinical and emerging clinical data suggest greater sensitivity to the effects of cannabinoids in women. SUMMARY: Cannabis is one of the most commonly used drugs with increasing rates of use. Women in particular may be at a greater risk of adverse outcomes given the previously described "telescoping effect" of substance use in women. Human data examining the sex- and gender-related differences in the effects of cannabinoids and factors underlying these differences are very limited. This represents a critical gap in the literature and needs to be systematically examined in future studies.
Entities:
Keywords:
Cannabis; THC; delta-9-tetrahydrocannabinol; endocannabinoid; gender; sex differences
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