Zhenyu Xiong1,2, Jiaying Li3, Xiangbin Zhong1,2, Shaozhao Zhang1,2, Xiuting Sun1,2, Huimin Zhou1,2, Yunzhi Chen4, Xiaodong Zhuang5,2,6, Xinxue Liao7,2. 1. The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. 2. NHC Key Laboratory on Assisted Circulation, Sun Yat-sen University, Guangzhou, China. 3. Nanfang Hospital of Southern Medical University, Guangzhou, China. 4. The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. 5. The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China zhuangxd3@mail.sysu.edu.cn. 6. Center for Information Technology & Statistics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. 7. The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China liaoxinx@mail.sysu.edu.cn.
Abstract
OBJECTIVE: To determine whether visit-to-visit fasting glucose (VVFG) variability in young adulthood is associated with midlife hippocampal integrity and volume. RESEARCH DESIGN AND METHODS: Multivariable-adjusted linear regression models were used to estimate the association between VVFG variability and brain MRI variables in 543 CARDIA study participants. VVFG variability was defined by the SD of FG (SDFG), the coefficient of variation of the mean FG (CVFG), and the average real variability (ARVFG) over 25 years of follow-up. Hippocampal integrity fractional anisotropy (FA) and tissue volume standardized to intracranial volume were measured by 3T MRI at year 25. RESULTS: After multivariable adjustment, higher FG variability (1-SD increase) was associated with lower hippocampal FA (SDFG -0.015 [95% CI -0.026, -0.004]; CVFG -0.009 [95% CI -0.018, -0.001]; ARVFG -0.011 [95% CI -0.019, -0.002]) and lower hippocampal volume (SDFG -0.012 [95% CI -0.023, -0.001]). CONCLUSIONS: Higher VVFG variability in young adulthood is associated with lower midlife hippocampal integrity and volume, suggesting its value in predicting risk for hippocampal structural damage.
OBJECTIVE: To determine whether visit-to-visit fasting glucose (VVFG) variability in young adulthood is associated with midlife hippocampal integrity and volume. RESEARCH DESIGN AND METHODS: Multivariable-adjusted linear regression models were used to estimate the association between VVFG variability and brain MRI variables in 543 CARDIA study participants. VVFG variability was defined by the SD of FG (SDFG), the coefficient of variation of the mean FG (CVFG), and the average real variability (ARVFG) over 25 years of follow-up. Hippocampal integrity fractional anisotropy (FA) and tissue volume standardized to intracranial volume were measured by 3T MRI at year 25. RESULTS: After multivariable adjustment, higher FG variability (1-SD increase) was associated with lower hippocampal FA (SDFG -0.015 [95% CI -0.026, -0.004]; CVFG -0.009 [95% CI -0.018, -0.001]; ARVFG -0.011 [95% CI -0.019, -0.002]) and lower hippocampal volume (SDFG -0.012 [95% CI -0.023, -0.001]). CONCLUSIONS: Higher VVFG variability in young adulthood is associated with lower midlife hippocampal integrity and volume, suggesting its value in predicting risk for hippocampal structural damage.
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