Literature DB >> 31548229

Dual-Specific Protein and Lipid Phosphatase PTEN and Its Biological Functions.

Taojian Tu1, Jingyu Chen1, Lulu Chen1, Bangyan L Stiles1,2.   

Abstract

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) encodes a 403-amino acid protein with an amino-terminal domain that shares sequence homology with the actin-binding protein tensin and the putative tyrosine-protein phosphatase auxilin. Crystal structure analysis of PTEN has revealed a C2 domain that binds to phospholipids in membranes and a phosphatase domain that displays dual-specific activity toward both tyrosine (Y), serine (S)/threonine (T), as well as lipid substrates in vitro. Characterized primarily as a lipid phosphatase, PTEN plays important roles in multiple cellular processes including cell growth/survival as well as metabolism.
Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2020        PMID： 31548229      PMCID： PMC6938656          DOI： 10.1101/cshperspect.a036301

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  130 in total

1.  Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein.

Authors:  Lorena Eguez; Adrian Lee; Jose A Chavez; Cristinel P Miinea; Susan Kane; Gustav E Lienhard; Timothy E McGraw
Journal:  Cell Metab       Date:  2005-10       Impact factor: 27.287

2.  The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.

Authors:  T Maehama; J E Dixon
Journal:  J Biol Chem       Date:  1998-05-29       Impact factor: 5.157

3.  CREB is a novel nuclear target of PTEN phosphatase.

Authors:  Tingting Gu; Zhong Zhang; Jianli Wang; Junyi Guo; Wen Hong Shen; Yuxin Yin
Journal:  Cancer Res       Date:  2011-03-08       Impact factor: 12.701

4.  Activation of phospholipase C delta1 through C2 domain by a Ca(2+)-enzyme-phosphatidylserine ternary complex.

Authors:  J W Lomasney; H F Cheng; S R Roffler; K King
Journal:  J Biol Chem       Date:  1999-07-30       Impact factor: 5.157

5.  Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases.

Authors:  J Liliental; S Y Moon; R Lesche; R Mamillapalli; D Li; Y Zheng; H Sun; H Wu
Journal:  Curr Biol       Date:  2000-04-06       Impact factor: 10.834

6.  Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression.

Authors:  Valeria Gabriela Antico Arciuch; Soledad Galli; María Clara Franco; Philip Y Lam; Enrique Cadenas; María Cecilia Carreras; Juan José Poderoso
Journal:  PLoS One       Date:  2009-10-21       Impact factor: 3.240

7.  Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition.

Authors:  Marcus D Goncalves; Emidio E Pistilli; Anthony Balduzzi; Morris J Birnbaum; Jennifer Lachey; Tejvir S Khurana; Rexford S Ahima
Journal:  PLoS One       Date:  2010-09-15       Impact factor: 3.240

Review 8.  PTEN and the PI3-kinase pathway in cancer.

Authors:  Nader Chalhoub; Suzanne J Baker
Journal:  Annu Rev Pathol       Date:  2009       Impact factor: 23.472

9.  Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected].

Authors:  Bangyan Stiles; Ying Wang; Andreas Stahl; Sara Bassilian; W Paul Lee; Yoon-Jung Kim; Robert Sherwin; Sherin Devaskar; Ralf Lesche; Mark A Magnuson; Hong Wu
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-09       Impact factor: 11.205

10.  Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice.

Authors:  Kai-Ting Yang; Jennifer-Ann Bayan; Ni Zeng; Richa Aggarwal; Lina He; Zhechu Peng; Anketse Kassa; Melissa Kim; Zhiou Luo; Zhenrong Shi; Vivian Medina; Keerthi Boddupally; Bangyan L Stiles
Journal:  Diabetologia       Date:  2013-10-26       Impact factor: 10.122
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  2 in total

1.  Chronic Exposure to Palmitic Acid Down-Regulates AKT in Beta-Cells through Activation of mTOR.

Authors:  Richa Aggarwal; Zhechu Peng; Ni Zeng; Joshua Silva; Lina He; Jingyu Chen; Anketse Debebe; Taojian Tu; Mario Alba; Chien-Yu Chen; Eileen X Stiles; Handan Hong; Bangyan L Stiles
Journal:  Am J Pathol       Date:  2021-10-05       Impact factor: 4.307

2.  PTEN inhibits AMPK to control collective migration.

Authors:  Florent Peglion; Lavinia Capuana; Isabelle Perfettini; Laurent Boucontet; Ben Braithwaite; Emma Colucci-Guyon; Emie Quissac; Karin Forsberg-Nilsson; Flora Llense; Sandrine Etienne-Manneville
Journal:  Nat Commun       Date:  2022-08-11       Impact factor: 17.694
  2 in total

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