| Literature DB >> 31546015 |
Sweta Bawari1, Devesh Tewari2, Sandro Argüelles3, Archana N Sah4, Seyed Fazel Nabavi5, Suowen Xu6, Rosa Anna Vacca7, Seyed Mohammad Nabavi8, Samira Shirooie9.
Abstract
Neurodegenerative disorders like Alzheimer's disease, Huntington's disease, Parkinson's disease, spinocerebellar ataxias, amyotrophic lateral sclerosis, frontotemporal dementia to prion diseases, Friedreich's ataxia, hereditary spastic paraplegia and optic atrophy type 1, and behavior disorders like neuropsychiatric, hyperactivity and autism spectrum disorders are closely associated with neurobiological deficits. Brain derived neurotrophic factor (BDNF) is an extensively studied neurotrophin. BDNF is essential for neuronal genesis, differentiation, survival, growth, plasticity, synaptic viability and transmission. BDNF has emerged as a promising target for regulating synaptic activity and plasticity. An overview of effects and mechanisms of the natural products targeting BDNF is described. This review is an attempt to enumerate the effects of various natural products on BDNF as a novel therapeutic approach for neurodegenerative and neuropsychiatric disorders.Entities:
Keywords: BDNF; Brain; Dementia; Neurodegeneration; Synapses
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Year: 2019 PMID： 31546015 DOI： 10.1016/j.phrs.2019.104458
Source DB: PubMed Journal: Pharmacol Res ISSN： 1043-6618 Impact factor: 7.658