OBJECTIVES: Many combat veterans exhibit cognitive limitations of uncertain origin. In this study, we examined factors that predict cognitive functioning by considering effects of blast-related concussion (BRC), non-blast-related concussion (NBRC), and posttraumatic stress disorder (PTSD) symptoms. Analyses specifically tested whether (a) BRC and NBRC were distinct in their prediction of cognitive performance; (b) a dose-response relationship existed between recurrent concussion (BRC and NBRC) and cognitive impairment; and (c) PTSD symptoms mediated the relationship between BRC and cognitive performance. METHOD: Two hundred eighty veterans with combat zone deployment histories completed semistructured clinical interviews to define BRC and NBRC histories, current and past mental health disorders, and dimensional ratings of PTSD symptomatology. Participants were also administered a number of neuropsychological measures to appraise cognitive functioning. RESULTS: A structural equation model (SEM) suggested that BRC and NBRC were not distinct in their prediction of cognitive performance, and there was no evidence that recurrent concussion (blast or nonblast) was directly associated with cognitive performance. BRC was significantly associated with PTSD symptoms (r = .24), PTSD symptoms were significantly associated with cognitive performance in the SEM (r = -.27), and PTSD symptoms significantly mediated the link between BRC and cognitive performance (p = .03). CONCLUSIONS: These results suggest that concussion history fails to directly contribute to cognitive performance, regardless of mechanism (blast or nonblast) and recurrence. BRC is nonetheless unique in its contribution to PTSD and PTSD-related cognitive deficits. Results support interventions specific to PTSD management in the interest of promoting neuropsychological functioning among war veterans. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
OBJECTIVES: Many combat veterans exhibit cognitive limitations of uncertain origin. In this study, we examined factors that predict cognitive functioning by considering effects of blast-related concussion (BRC), non-blast-related concussion (NBRC), and posttraumatic stress disorder (PTSD) symptoms. Analyses specifically tested whether (a) BRC and NBRC were distinct in their prediction of cognitive performance; (b) a dose-response relationship existed between recurrent concussion (BRC and NBRC) and cognitive impairment; and (c) PTSD symptoms mediated the relationship between BRC and cognitive performance. METHOD: Two hundred eighty veterans with combat zone deployment histories completed semistructured clinical interviews to define BRC and NBRC histories, current and past mental health disorders, and dimensional ratings of PTSD symptomatology. Participants were also administered a number of neuropsychological measures to appraise cognitive functioning. RESULTS: A structural equation model (SEM) suggested that BRC and NBRC were not distinct in their prediction of cognitive performance, and there was no evidence that recurrent concussion (blast or nonblast) was directly associated with cognitive performance. BRC was significantly associated with PTSD symptoms (r = .24), PTSD symptoms were significantly associated with cognitive performance in the SEM (r = -.27), and PTSD symptoms significantly mediated the link between BRC and cognitive performance (p = .03). CONCLUSIONS: These results suggest that concussion history fails to directly contribute to cognitive performance, regardless of mechanism (blast or nonblast) and recurrence. BRC is nonetheless unique in its contribution to PTSD and PTSD-related cognitive deficits. Results support interventions specific to PTSD management in the interest of promoting neuropsychological functioning among war veterans. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
Authors: Nathaniel W Nelson; James B Hoelzle; Kathryn A McGuire; Amanda G Ferrier-Auerbach; Molly J Charlesworth; Scott R Sponheim Journal: Arch Clin Neuropsychol Date: 2010-10-05 Impact factor: 2.813
Authors: Michael S Xydakis; Vikhyat S Bebarta; Corey D Harrison; Jonathan C Conner; Gerald A Grant; Anthony S Robbins Journal: N Engl J Med Date: 2007-08-23 Impact factor: 91.245
Authors: Nathaniel W Nelson; James B Hoelzle; Kathryn A McGuire; Amanda G Ferrier-Auerbach; Molly J Charlesworth; Scott R Sponheim Journal: Brain Inj Date: 2011-03-15 Impact factor: 2.311
Authors: Kerry Donnelly; James P Donnelly; Gary C Warner; C James Kittleson; Paul R King Journal: Clin Neuropsychol Date: 2017-10-20 Impact factor: 3.535
Authors: Kathleen F Pagulayan; Holly Rau; Renee Madathil; Madeleine Werhane; Steven P Millard; Eric C Petrie; Brett Parmenter; Sarah Peterson; Scott Sorg; Rebecca Hendrickson; Cindy Mayer; James S Meabon; Bertrand R Huber; Murray Raskind; David G Cook; Elaine R Peskind Journal: J Int Neuropsychol Soc Date: 2017-12-29 Impact factor: 2.892
Authors: Jared A Rowland; Jennifer R Stapleton-Kotloski; Sarah L Martindale; Emily E Rogers; Anna S Ord; Dwayne W Godwin; Katherine H Taber Journal: J Neurotrauma Date: 2021-11-15 Impact factor: 5.269
Authors: David F Tate; Emily L Dennis; John T Adams; Maheen M Adamson; Heather G Belanger; Erin D Bigler; Heather C Bouchard; Alexandra L Clark; Lisa M Delano-Wood; Seth G Disner; Blessen C Eapen; Carol E Franz; Elbert Geuze; Naomi J Goodrich-Hunsaker; Kihwan Han; Jasmeet P Hayes; Sidney R Hinds; Cooper B Hodges; Elizabeth S Hovenden; Andrei Irimia; Kimbra Kenney; Inga K Koerte; William S Kremen; Harvey S Levin; Hannah M Lindsey; Rajendra A Morey; Mary R Newsome; John Ollinger; Mary Jo Pugh; Randall S Scheibel; Martha E Shenton; Danielle R Sullivan; Brian A Taylor; Maya Troyanskaya; Carmen Velez; Benjamin Sc Wade; Xin Wang; Ashley L Ware; Ross Zafonte; Paul M Thompson; Elisabeth A Wilde Journal: Brain Imaging Behav Date: 2021-01-07 Impact factor: 3.978
Authors: Oshin Vartanian; Catherine Tenn; Shawn G Rhind; Ann Nakashima; Alex P Di Battista; Lauren E Sergio; Diana J Gorbet; Douglas D Fraser; Angela Colantonio; Kristen King; Quan Lam; Doug Saunders; Rakesh Jetly Journal: Front Neurol Date: 2020-12-03 Impact factor: 4.003
Authors: Donald D McGeary; Donald B Penzien; Patricia A Resick; Cindy A McGeary; Carlos A Jaramillo; Blessen C Eapen; Stacey Young-McCaughan; Paul S Nabity; John C Moring; Timothy T Houle; Terence M Keane; Alan L Peterson Journal: Contemp Clin Trials Commun Date: 2021-01-06
Authors: Brian L Edlow; Yelena G Bodien; Timothy Baxter; Heather G Belanger; Ryan J Cali; Katryna B Deary; Bruce Fischl; Andrea S Foulkes; Natalie Gilmore; Douglas N Greve; Jacob M Hooker; Susie Y Huang; Jessica N Kelemen; W Taylor Kimberly; Chiara Maffei; Maryam Masood; Daniel P Perl; Jonathan R Polimeni; Bruce R Rosen; Samantha L Tromly; Chieh-En J Tseng; Eveline F Yao; Nicole R Zürcher; Christine L Mac Donald; Kristen Dams-O'Connor Journal: J Neurotrauma Date: 2022-06-29 Impact factor: 4.869