Literature DB >> 31545351

Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group.

Marguerite R Irvin1, Colleen M Sitlani2, James S Floyd2, Bruce M Psaty2,3,4,5, Joshua C Bis2, Kerri L Wiggins2, Eric A Whitsel6,7, Til Sturmer7, James Stewart7, Laura Raffield8, Fangui Sun9, Ching-Ti Liu9, Hanfei Xu9, Adrienne L Cupples9, Rikki M Tanner1, Peter Rossing10, Albert Smith11,12, Nuno R Zilhão11, Lenore J Launer13, Raymond Noordam14, Jerome I Rotter15, Jie Yao15, Xiaohui Li15, Xiuqing Guo15, Nita Limdi16, Aishwarya Sundaresan17, Leslie Lange18, Adolfo Correa19, David J Stott20, Ian Ford21, J Wouter Jukema22, Vilmundur Gudnason23,24, Dennis O Mook-Kanamori14, Stella Trompet14, Walter Palmas25, Helen R Warren26,27, Jacklyn N Hellwege28,29, Ayush Giri28,30, Christopher O'donnell31,32, Adriana M Hung28,33, Todd L Edwards28,34, Tarunveer S Ahluwalia1,10, Donna K Arnett35, Christy L Avery7.   

Abstract

BACKGROUND: Only a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described.
METHODS: We conducted a case-control genome-wide association study of aTRH among persons treated for hypertension, using data from 10 cohorts of European ancestry (EA) and 5 cohorts of African ancestry (AA). Cases were treated with 3 different antihypertensive medication classes and had blood pressure (BP) above goal (systolic BP ≥ 140 mm Hg and/or diastolic BP ≥ 90 mm Hg) or 4 or more medication classes regardless of BP control (nEA = 931, nAA = 228). Both a normotensive control group and a treatment-responsive control group were considered in separate analyses. Normotensive controls were untreated (nEA = 14,210, nAA = 2,480) and had systolic BP/diastolic BP < 140/90 mm Hg. Treatment-responsive controls (nEA = 5,266, nAA = 1,817) had BP at goal (<140/90 mm Hg), while treated with one antihypertensive medication class. Individual cohorts used logistic regression with adjustment for age, sex, study site, and principal components for ancestry to examine the association of single-nucleotide polymorphisms with case-control status. Inverse variance-weighted fixed-effects meta-analyses were carried out using METAL.
RESULTS: The known hypertension locus, CASZ1, was a top finding among EAs (P = 1.1 × 10-8) and in the race-combined analysis (P = 1.5 × 10-9) using the normotensive control group (rs12046278, odds ratio = 0.71 (95% confidence interval: 0.6-0.8)). Single-nucleotide polymorphisms in this locus were robustly replicated in the Million Veterans Program (MVP) study in consideration of a treatment-responsive control group. There were no statistically significant findings for the discovery analyses including treatment-responsive controls.
CONCLUSION: This genomic discovery effort for aTRH identified CASZ1 as an aTRH risk locus. © American Journal of Hypertension, Ltd 2019. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  blood pressure; genome-wide association study; hypertension; severe hypertension; treatment-resistant hypertension

Mesh：

Substances：

Year:  2019        PMID： 31545351      PMCID： PMC6856621          DOI： 10.1093/ajh/hpz150

Source DB:  PubMed          Journal:  Am J Hypertens        ISSN： 0895-7061            Impact factor:   3.080


  20 in total

1.  Blood pressure and hypertension are associated with 7 loci in the Japanese population.

Authors:  Fumihiko Takeuchi; Masato Isono; Tomohiro Katsuya; Ken Yamamoto; Mitsuhiro Yokota; Takao Sugiyama; Toru Nabika; Akihiro Fujioka; Keizo Ohnaka; Hiroyuki Asano; Yukio Yamori; Shuhei Yamaguchi; Shotai Kobayashi; Ryoichi Takayanagi; Toshio Ogihara; Norihiro Kato
Journal:  Circulation       Date:  2010-05-17       Impact factor: 29.690

2.  Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes.

Authors:  Sarah M Schumacher-Bass; Eileen D Vesely; Lian Zhang; Katherine E Ryland; Dyke P McEwen; Priscilla J Chan; Chad R Frasier; Jeremy C McIntyre; Robin M Shaw; Jeffrey R Martens
Journal:  Circ Res       Date:  2014-02-07       Impact factor: 17.367

3.  CASZ1 loss-of-function mutation associated with congenital heart disease.

Authors:  Ri-Tai Huang; Song Xue; Juan Wang; Jian-Yun Gu; Jia-Hong Xu; Yan-Jie Li; Ning Li; Xiao-Xiao Yang; Hua Liu; Xiao-Dong Zhang; Xin-Kai Qu; Ying-Jia Xu; Xing-Biao Qiu; Ruo-Gu Li; Yi-Qing Yang
Journal:  Gene       Date:  2016-09-28       Impact factor: 3.688

4.  Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association.

Authors:  Robert M Carey; David A Calhoun; George L Bakris; Robert D Brook; Stacie L Daugherty; Cheryl R Dennison-Himmelfarb; Brent M Egan; John M Flack; Samuel S Gidding; Eric Judd; Daniel T Lackland; Cheryl L Laffer; Christopher Newton-Cheh; Steven M Smith; Sandra J Taler; Stephen C Textor; Tanya N Turan; William B White
Journal:  Hypertension       Date:  2018-11       Impact factor: 10.190

5.  Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research.

Authors:  David A Calhoun; Daniel Jones; Stephen Textor; David C Goff; Timothy P Murphy; Robert D Toto; Anthony White; William C Cushman; William White; Domenic Sica; Keith Ferdinand; Thomas D Giles; Bonita Falkner; Robert M Carey
Journal:  Circulation       Date:  2008-06-24       Impact factor: 29.690

6.  Genome-wide association analysis of common genetic variants of resistant hypertension.

Authors:  Nihal El Rouby; Caitrin W McDonough; Yan Gong; Leslie A McClure; Braxton D Mitchell; Richard B Horenstein; Robert L Talbert; Dana C Crawford; Matthew A Gitzendanner; Atsushi Takahashi; Toshihiro Tanaka; Michiaki Kubo; Carl J Pepine; Rhonda M Cooper-DeHoff; Oscar R Benavente; Alan R Shuldiner; Julie A Johnson
Journal:  Pharmacogenomics J       Date:  2018-09-20       Impact factor: 3.550

7.  Large-scale gene-centric analysis identifies polymorphisms for resistant hypertension.

Authors:  Vanessa Fontana; Caitrin W McDonough; Yan Gong; Nihal M El Rouby; Ana Caroline C Sá; Kent D Taylor; Y-D Ida Chen; John G Gums; Arlene B Chapman; Stephen T Turner; Carl J Pepine; Julie A Johnson; Rhonda M Cooper-DeHoff
Journal:  J Am Heart Assoc       Date:  2014-11-10       Impact factor: 5.501

8.  Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

Authors:  Helen R Warren; Evangelos Evangelou; Claudia P Cabrera; He Gao; Meixia Ren; Borbala Mifsud; Ioanna Ntalla; Praveen Surendran; Chunyu Liu; James P Cook; Aldi T Kraja; Fotios Drenos; Marie Loh; Niek Verweij; Jonathan Marten; Ibrahim Karaman; Marcelo P Segura Lepe; Paul F O'Reilly; Joanne Knight; Harold Snieder; Norihiro Kato; Jiang He; E Shyong Tai; M Abdullah Said; David Porteous; Maris Alver; Neil Poulter; Martin Farrall; Ron T Gansevoort; Sandosh Padmanabhan; Reedik Mägi; Alice Stanton; John Connell; Stephan J L Bakker; Andres Metspalu; Denis C Shields; Simon Thom; Morris Brown; Peter Sever; Tõnu Esko; Caroline Hayward; Pim van der Harst; Danish Saleheen; Rajiv Chowdhury; John C Chambers; Daniel I Chasman; Aravinda Chakravarti; Christopher Newton-Cheh; Cecilia M Lindgren; Daniel Levy; Jaspal S Kooner; Bernard Keavney; Maciej Tomaszewski; Nilesh J Samani; Joanna M M Howson; Martin D Tobin; Patricia B Munroe; Georg B Ehret; Louise V Wain
Journal:  Nat Genet       Date:  2017-01-30       Impact factor: 38.330

9.  Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

Authors:  Ayush Giri; Jacklyn N Hellwege; Jacob M Keaton; Jihwan Park; Chengxiang Qiu; Helen R Warren; Eric S Torstenson; Csaba P Kovesdy; Yan V Sun; Otis D Wilson; Cassianne Robinson-Cohen; Christianne L Roumie; Cecilia P Chung; Kelly A Birdwell; Scott M Damrauer; Scott L DuVall; Derek Klarin; Kelly Cho; Yu Wang; Evangelos Evangelou; Claudia P Cabrera; Louise V Wain; Rojesh Shrestha; Brian S Mautz; Elvis A Akwo; Muralidharan Sargurupremraj; Stéphanie Debette; Michael Boehnke; Laura J Scott; Jian'an Luan; Jing-Hua Zhao; Sara M Willems; Sébastien Thériault; Nabi Shah; Christopher Oldmeadow; Peter Almgren; Ruifang Li-Gao; Niek Verweij; Thibaud S Boutin; Massimo Mangino; Ioanna Ntalla; Elena Feofanova; Praveen Surendran; James P Cook; Savita Karthikeyan; Najim Lahrouchi; Chunyu Liu; Nuno Sepúlveda; Tom G Richardson; Aldi Kraja; Philippe Amouyel; Martin Farrall; Neil R Poulter; Markku Laakso; Eleftheria Zeggini; Peter Sever; Robert A Scott; Claudia Langenberg; Nicholas J Wareham; David Conen; Colin Neil Alexander Palmer; John Attia; Daniel I Chasman; Paul M Ridker; Olle Melander; Dennis Owen Mook-Kanamori; Pim van der Harst; Francesco Cucca; David Schlessinger; Caroline Hayward; Tim D Spector; Marjo-Riitta Jarvelin; Branwen J Hennig; Nicholas J Timpson; Wei-Qi Wei; Joshua C Smith; Yaomin Xu; Michael E Matheny; Edward E Siew; Cecilia Lindgren; Karl-Heinz Herzig; George Dedoussis; Joshua C Denny; Bruce M Psaty; Joanna M M Howson; Patricia B Munroe; Christopher Newton-Cheh; Mark J Caulfield; Paul Elliott; J Michael Gaziano; John Concato; Peter W F Wilson; Philip S Tsao; Digna R Velez Edwards; Katalin Susztak; Christopher J O'Donnell; Adriana M Hung; Todd L Edwards
Journal:  Nat Genet       Date:  2018-12-21       Impact factor: 38.330

10.  Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

Authors:  Praveen Surendran; Fotios Drenos; Robin Young; Helen Warren; James P Cook; Alisa K Manning; Niels Grarup; Xueling Sim; Danish Saleheen; Folkert W Asselbergs; Cecilia M Lindgren; John Danesh; Louise V Wain; Adam S Butterworth; Joanna Mm Howson; Patricia B Munroe; Daniel R Barnes; Kate Witkowska; James R Staley; Vinicius Tragante; Taru Tukiainen; Hanieh Yaghootkar; Nicholas Masca; Daniel F Freitag; Teresa Ferreira; Olga Giannakopoulou; Andrew Tinker; Magdalena Harakalova; Evelin Mihailov; Chunyu Liu; Aldi T Kraja; Sune Fallgaard Nielsen; Asif Rasheed; Maria Samuel; Wei Zhao; Lori L Bonnycastle; Anne U Jackson; Narisu Narisu; Amy J Swift; Lorraine Southam; Jonathan Marten; Jeroen R Huyghe; Alena Stančáková; Cristiano Fava; Therese Ohlsson; Angela Matchan; Kathleen E Stirrups; Jette Bork-Jensen; Anette P Gjesing; Jukka Kontto; Markus Perola; Susan Shaw-Hawkins; Aki S Havulinna; He Zhang; Louise A Donnelly; Christopher J Groves; N William Rayner; Matt J Neville; Neil R Robertson; Andrianos M Yiorkas; Karl-Heinz Herzig; Eero Kajantie; Weihua Zhang; Sara M Willems; Lars Lannfelt; Giovanni Malerba; Nicole Soranzo; Elisabetta Trabetti; Niek Verweij; Evangelos Evangelou; Alireza Moayyeri; Anne-Claire Vergnaud; Christopher P Nelson; Alaitz Poveda; Tibor V Varga; Muriel Caslake; Anton Jm de Craen; Stella Trompet; Jian'an Luan; Robert A Scott; Sarah E Harris; David Cm Liewald; Riccardo Marioni; Cristina Menni; Aliki-Eleni Farmaki; Göran Hallmans; Frida Renström; Jennifer E Huffman; Maija Hassinen; Stephen Burgess; Ramachandran S Vasan; Janine F Felix; Maria Uria-Nickelsen; Anders Malarstig; Dermot F Reily; Maarten Hoek; Thomas Vogt; Honghuang Lin; Wolfgang Lieb; Matthew Traylor; Hugh F Markus; Heather M Highland; Anne E Justice; Eirini Marouli; Jaana Lindström; Matti Uusitupa; Pirjo Komulainen; Timo A Lakka; Rainer Rauramaa; Ozren Polasek; Igor Rudan; Olov Rolandsson; Paul W Franks; George Dedoussis; Timothy D Spector; Pekka Jousilahti; Satu Männistö; Ian J Deary; John M Starr; Claudia Langenberg; Nick J Wareham; Morris J Brown; Anna F Dominiczak; John M Connell; J Wouter Jukema; Naveed Sattar; Ian Ford; Chris J Packard; Tõnu Esko; Reedik Mägi; Andres Metspalu; Rudolf A de Boer; Peter van der Meer; Pim van der Harst; Giovanni Gambaro; Erik Ingelsson; Lars Lind; Paul Iw de Bakker; Mattijs E Numans; Ivan Brandslund; Cramer Christensen; Eva Rb Petersen; Eeva Korpi-Hyövälti; Heikki Oksa; John C Chambers; Jaspal S Kooner; Alexandra If Blakemore; Steve Franks; Marjo-Riitta Jarvelin; Lise L Husemoen; Allan Linneberg; Tea Skaaby; Betina Thuesen; Fredrik Karpe; Jaakko Tuomilehto; Alex Sf Doney; Andrew D Morris; Colin Na Palmer; Oddgeir Lingaas Holmen; Kristian Hveem; Cristen J Willer; Tiinamaija Tuomi; Leif Groop; AnneMari Käräjämäki; Aarno Palotie; Samuli Ripatti; Veikko Salomaa; Dewan S Alam; Abdulla Al Shafi Majumder; Emanuele Di Angelantonio; Rajiv Chowdhury; Mark I McCarthy; Neil Poulter; Alice V Stanton; Peter Sever; Philippe Amouyel; Dominique Arveiler; Stefan Blankenberg; Jean Ferrières; Frank Kee; Kari Kuulasmaa; Martina Müller-Nurasyid; Giovanni Veronesi; Jarmo Virtamo; Panos Deloukas; Paul Elliott; Eleftheria Zeggini; Sekar Kathiresan; Olle Melander; Johanna Kuusisto; Markku Laakso; Sandosh Padmanabhan; David Porteous; Caroline Hayward; Generation Scotland; Francis S Collins; Karen L Mohlke; Torben Hansen; Oluf Pedersen; Michael Boehnke; Heather M Stringham; Philippe Frossard; Christopher Newton-Cheh; Martin D Tobin; Børge Grønne Nordestgaard; Mark J Caulfield; Anubha Mahajan; Andrew P Morris; Maciej Tomaszewski; Nilesh J Samani
Journal:  Nat Genet       Date:  2016-09-12       Impact factor: 38.330
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  2 in total

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Journal:  Sci Rep       Date:  2021-09-30       Impact factor: 4.379

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Authors:  Edith Le Floch; Teresa Cosentino; Casper K Larsen; Felix Beuschlein; Martin Reincke; Laurence Amar; Gian-Paolo Rossi; Kelly De Sousa; Stéphanie Baron; Sophie Chantalat; Benjamin Saintpierre; Livia Lenzini; Arthur Frouin; Isabelle Giscos-Douriez; Matthis Ferey; Alaa B Abdellatif; Tchao Meatchi; Jean-Philippe Empana; Xavier Jouven; Christian Gieger; Melanie Waldenberger; Annette Peters; Daniele Cusi; Erika Salvi; Pierre Meneton; Mathilde Touvier; Mélanie Deschasaux; Nathalie Druesne-Pecollo; Sheerazed Boulkroun; Fabio L Fernandes-Rosa; Jean-François Deleuze; Xavier Jeunemaitre; Maria-Christina Zennaro
Journal:  Nat Commun       Date:  2022-09-03       Impact factor: 17.694
  2 in total

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