Literature DB >> 31544596

The role of dNTP metabolites in control of the embryonic cell cycle.

Boyang Liu1, Jörg Großhans1,2.   

Abstract

Deoxyribonucleotide metabolites (dNTPs) are the substrates for DNA synthesis. It has been proposed that their availability influences the progression of the cell cycle during development and pathological situations such as tumor growth. The mechanism has remained unclear for the link between cell cycle and dNTP levels beyond their role as substrates. Here, we review recent studies concerned with the dynamics of dNTP levels in early embryos and the role of DNA replication checkpoint as a sensor of dNTP levels.

Entities:  

Keywords:  DNA replication checkpoint; Drosophila; deoxyribonucleotide; metabolism; nuclear cycle; ribonucleotide reductase

Year:  2019        PMID： 31544596      PMCID： PMC6791698          DOI： 10.1080/15384101.2019.1665948

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  109 in total

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Authors:  Antony W Shermoen; Mark L McCleland; Patrick H O'Farrell
Journal:  Curr Biol       Date:  2010-11-11       Impact factor: 10.834

2.  Genome wide decrease of DNA replication eye density at the midblastula transition of Xenopus laevis.

Authors:  Marie Platel; Hemalatha Narassimprakash; Diletta Ciardo; Olivier Haccard; Kathrin Marheineke
Journal:  Cell Cycle       Date:  2019-05-26       Impact factor: 4.534

3.  High speed of fork progression induces DNA replication stress and genomic instability.

Authors:  Apolinar Maya-Mendoza; Pavel Moudry; Joanna Maria Merchut-Maya; MyungHee Lee; Robert Strauss; Jiri Bartek
Journal:  Nature       Date:  2018-06-27       Impact factor: 49.962

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5.  Number of nuclear divisions in the Drosophila blastoderm controlled by onset of zygotic transcription.

Authors:  Hung-wei Sung; Saskia Spangenberg; Nina Vogt; Jörg Großhans
Journal:  Curr Biol       Date:  2013-01-03       Impact factor: 10.834

6.  Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast.

Authors:  Davide Mantiero; Amanda Mackenzie; Anne Donaldson; Philip Zegerman
Journal:  EMBO J       Date:  2011-11-11       Impact factor: 11.598

7.  The Drosophila mitotic inhibitor Frühstart specifically binds to the hydrophobic patch of cyclins.

Authors:  Pawel Gawliński; Rainer Nikolay; Catherine Goursot; Steffen Lawo; Bhagirath Chaurasia; Hans-Martin Herz; Yvonne Kussler-Schneider; Thomas Ruppert; Matthias Mayer; Jörg Grosshans
Journal:  EMBO Rep       Date:  2007-04-13       Impact factor: 8.807

8.  Remodeling of the metabolome during early frog development.

Authors:  Livia Vastag; Paul Jorgensen; Leonid Peshkin; Ru Wei; Joshua D Rabinowitz; Marc W Kirschner
Journal:  PLoS One       Date:  2011-02-04       Impact factor: 3.240

9.  Modified nucleoside triphosphates exist in mammals.

Authors:  Han-Peng Jiang; Jun Xiong; Fei-Long Liu; Cheng-Jie Ma; Xing-Lin Tang; Bi-Feng Yuan; Yu-Qi Feng
Journal:  Chem Sci       Date:  2018-04-02       Impact factor: 9.825

10.  Mammalian S-phase checkpoint integrity is dependent on transformation status and purine deoxyribonucleosides.

Authors:  C S Downes; C Z Bachrati; S J Devlin; M Tommasino; T J Cutts; J V Watson; I Raskó; R T Johnson
Journal:  J Cell Sci       Date:  2000-03       Impact factor: 5.285
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  5 in total

1.  MTBSTFA derivatization-LC-MS/MS approach for the quantitative analysis of endogenous nucleotides in human colorectal carcinoma cells.

Authors:  Huixia Zhang; Yan Li; Zheng Li; Christopher Wai-Kei Lam; Peng Zhu; Caiyun Wang; Hua Zhou; Wei Zhang
Journal:  J Pharm Anal       Date:  2021-01-22

2.  Fluorescence fluctuation analysis reveals PpV dependent Cdc25 protein dynamics in living embryos.

Authors:  Boyang Liu; Ingo Gregor; H-Arno Müller; Jörg Großhans
Journal:  PLoS Genet       Date:  2020-04-06       Impact factor: 5.917

3.  lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.

Authors:  Guibin Liang; Menghao Zeng; Min Gao; Wei Xing; Xin Jin; Qianlu Wang; Longtian Deng; Hao Ou; Zhihui He
Journal:  Oxid Med Cell Longev       Date:  2022-01-17       Impact factor: 6.543

4.  Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders.

Authors:  Junmei Hu Frisk; Stefan Örn; Gunnar Pejler; Staffan Eriksson; Liya Wang
Journal:  BMC Neurosci       Date:  2022-03-27       Impact factor: 3.288

5.  dNTPpoolDB: a manually curated database of experimentally determined dNTP pools and pool changes in biological samples.

Authors:  Rita Pancsa; Erzsébet Fichó; Dániel Molnár; Éva Viola Surányi; Tamás Trombitás; Dóra Füzesi; Hanna Lóczi; Péter Szijjártó; Rita Hirmondó; Judit E Szabó; Judit Tóth
Journal:  Nucleic Acids Res       Date:  2022-01-07       Impact factor: 16.971
  5 in total

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