| Literature DB >> 31544514 |
Dao Duc Thien1, Trinh Thi Thuy1,2, Nguyen Thi Hoang Anh1,2, Le Quoc Thang3, Tran Duc Dai4, Nguyen Hoang Sa5, Nguyen Thanh Tam1,2.
Abstract
A new isoflavanone, (3S)-5,7-dihydroxy-2',3',4'-trimethoxy-6,5'-diprenylisoflavanone (1) and eight known compounds including five flavones (2-6), two triterpenes (7-8) and a steroid (9) were isolated from the whole plant of Uraria crinita (Leguminosae). The structure of 1 was elucidated by detailed spectroscopic means including IR, HR-ESI-MS, 1D and 2D NMR, and CD data. Compounds 1-9 were evaluated for their cytotoxicity against four human cancer cell lines KB (mouth epidermal carcinoma), HepG2 (hepatocellular carcinoma), Lu (lung carcinoma) and MCF7 (breast carcinoma). Compound 1 showed cytotoxic activity against the tested cell lines with IC50 values of 33.2, 29.4, 59.6 and 66.8 μM, respectively.Entities:
Keywords: (3S)-5,7-dihydroxy-2′,3′,4′-trimethoxy-6,5′-diprenylisoflavanone; Leguminosae; Uraria crinita; cytotoxicity
Year: 2019 PMID： 31544514 DOI： 10.1080/14786419.2019.1667352
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861