Literature DB >> 31544462

1,6-Conjugate-Addition-Induced [2 + 1] Annulation of para-Quinone Methides and Pyrazolones: Synthesis of Bis-Spiro Compounds with Contiguous Quaternary Spiro-Centers.

Someshwar B Kale1,2, Popat K Jori1, Thanusha Thatikonda1, Rajesh G Gonnade3,2, Utpal Das1,2.   

Abstract

A diastereoselective formal 1,6-conjugate-addition-mediated [2 + 1] annulation reaction using p-quinone methides and pyrazolones has been described. The corresponding bis-spiro[cyclohexadienone-cyclopropane-pyrazolone] compounds were obtained in very good yield under mild reaction conditions.

Entities:  

Year:  2019        PMID： 31544462     DOI： 10.1021/acs.orglett.9b02641

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  CF3-Containing para-Quinone Methides for Organic Synthesis.

Authors:  Michael Winter; Roman Schütz; Andreas Eitzinger; Armin R Ofial; Mario Waser
Journal:  European J Org Chem       Date:  2020-03-06

2.  Selective sulfonylation and isonitrilation of para-quinone methides employing TosMIC as a source of sulfonyl group or isonitrile group.

Authors:  Chuanhua Qu; Run Huang; Yong Li; Tong Liu; Yuan Chen; Guiting Song
Journal:  Beilstein J Org Chem       Date:  2021-12-02       Impact factor: 2.883
  2 in total

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