Literature DB >> 31544239

PharmVar GeneFocus: CYP2D6.

Charity Nofziger1, Amy J Turner2,3, Katrin Sangkuhl4, Michelle Whirl-Carrillo4, José A G Agúndez5,6, John L Black7, Henry M Dunnenberger8, Gualberto Ruano9, Martin A Kennedy10, Michael S Phillips11, Houda Hachad12, Teri E Klein4, Andrea Gaedigk13,14.   

Abstract

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).
© 2019 The Authors Clinical Pharmacology & Therapeutics © 2019 American Society for Clinical Pharmacology and Therapeutics.

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Year:  2019        PMID： 31544239      PMCID： PMC6925641          DOI： 10.1002/cpt.1643

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  100 in total

1.  Detection and characterization of the CYP2D6*9x2 gene duplication in two Spanish populations: resolution of AmpliChip CYP450 test no-calls.

Authors:  Andrea Gaedigk; Juanjo Hernandez; Virginia García-Solaesa; Santiago Sánchez; Maria Isidoro-García
Journal:  Pharmacogenomics       Date:  2011-11       Impact factor: 2.533

2.  Standardized Biogeographic Grouping System for Annotating Populations in Pharmacogenetic Research.

Authors:  Rachel Huddart; Alison E Fohner; Michelle Whirl-Carrillo; Genevieve L Wojcik; Christopher R Gignoux; Alice B Popejoy; Carlos D Bustamante; Russ B Altman; Teri E Klein
Journal:  Clin Pharmacol Ther       Date:  2019-01-21       Impact factor: 6.875

3.  In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles.

Authors:  Daniel L Hertz; Anna C Snavely; Howard L McLeod; Christine M Walko; Joseph G Ibrahim; Steven Anderson; Karen E Weck; Gustav Magrinat; Oludamilola Olajide; Susan Moore; Rachel Raab; Daniel R Carrizosa; Steven Corso; Garry Schwartz; Jeffrey M Peppercorn; James P Evans; David R Jones; Zeruesenay Desta; David A Flockhart; Lisa A Carey; William J Irvin
Journal:  Br J Clin Pharmacol       Date:  2015-08-02       Impact factor: 4.335

Review 4.  Recommendations for Clinical CYP2C19 Genotyping Allele Selection: A Report of the Association for Molecular Pathology.

Authors:  Victoria M Pratt; Andria L Del Tredici; Houda Hachad; Yuan Ji; Lisa V Kalman; Stuart A Scott; Karen E Weck
Journal:  J Mol Diagn       Date:  2018-02-21       Impact factor: 5.568

5.  Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.

Authors:  J K Hicks; K Sangkuhl; J J Swen; V L Ellingrod; D J Müller; K Shimoda; J R Bishop; E D Kharasch; T C Skaar; A Gaedigk; H M Dunnenberger; T E Klein; K E Caudle; J C Stingl
Journal:  Clin Pharmacol Ther       Date:  2017-02-13       Impact factor: 6.875

6.  Allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes.

Authors:  Ibrahim Numanagić; Salem Malikić; Michael Ford; Xiang Qin; Lorraine Toji; Milan Radovich; Todd C Skaar; Victoria M Pratt; Bonnie Berger; Steve Scherer; S Cenk Sahinalp
Journal:  Nat Commun       Date:  2018-02-26       Impact factor: 14.919

7.  Cypiripi: exact genotyping of CYP2D6 using high-throughput sequencing data.

Authors:  Ibrahim Numanagić; Salem Malikić; Victoria M Pratt; Todd C Skaar; David A Flockhart; S Cenk Sahinalp
Journal:  Bioinformatics       Date:  2015-06-15       Impact factor: 6.937

8.  Flexible and Scalable Full-Length CYP2D6 Long Amplicon PacBio Sequencing.

Authors:  Henk P J Buermans; Rolf H A M Vossen; Seyed Yahya Anvar; William G Allard; Henk-Jan Guchelaar; Stefan J White; Johan T den Dunnen; Jesse J Swen; Tahar van der Straaten
Journal:  Hum Mutat       Date:  2017-01-18       Impact factor: 4.878

9.  Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process.

Authors:  Kelly E Caudle; Teri E Klein; James M Hoffman; Daniel J Muller; Michelle Whirl-Carrillo; Li Gong; Ellen M McDonagh; Katrin Sangkuhl; Caroline F Thorn; Matthias Schwab; Jose A G Agundez; Robert R Freimuth; Vojtech Huser; Ming Ta Michael Lee; Otito F Iwuchukwu; Kristine R Crews; Stuart A Scott; Mia Wadelius; Jesse J Swen; Rachel F Tyndale; C Michael Stein; Dan Roden; Mary V Relling; Marc S Williams; Samuel G Johnson
Journal:  Curr Drug Metab       Date:  2014-02       Impact factor: 3.731

10.  Standardizing terms for clinical pharmacogenetic test results: consensus terms from the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Authors:  Kelly E Caudle; Henry M Dunnenberger; Robert R Freimuth; Josh F Peterson; Jonathan D Burlison; Michelle Whirl-Carrillo; Stuart A Scott; Heidi L Rehm; Marc S Williams; Teri E Klein; Mary V Relling; James M Hoffman
Journal:  Genet Med       Date:  2016-07-21       Impact factor: 8.822
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  58 in total

Review 1.  Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia.

Authors:  Ramon Cacabelos
Journal:  Int J Mol Sci       Date:  2020-04-26       Impact factor: 5.923

2.  CYP2D6 genetic variation in Ugandans.

Authors:  Jun Miura; Celestino Obua; Catherine Abbo; Tomonori Tateishi; Sunao Kaneko
Journal:  Eur J Clin Pharmacol       Date:  2021-08-27       Impact factor: 2.953

3.  Correlation of 1846G>A Polymorphism of CYP2D6 Gene with Haloperidol Efficacy and Safety in Patients with Alcoholic Hallucinoses.

Authors:  A A Parkhomenko; M S Zastrozhin; VYu Skryabin; V A Ivanchenko; S A Pozdniakov; V V Noskov; I A Zaytsev; N P Denisenko; K A Akmalova; E A Bryun; D A Sychev
Journal:  Psychopharmacol Bull       Date:  2022-06-27

4.  A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence.

Authors:  J Steven Leeder; Andrea Gaedigk; Krista J Wright; Vincent S Staggs; Sarah E Soden; Yvonne S Lin; Robin E Pearce
Journal:  Clin Transl Sci       Date:  2022-08-23       Impact factor: 4.438

Review 5.  PharmVar GeneFocus: CYP2C19.

Authors:  Mariana R Botton; Michelle Whirl-Carrillo; Andria L Del Tredici; Katrin Sangkuhl; Larisa H Cavallari; José A G Agúndez; Jorge Duconge; Ming Ta Michael Lee; Erica L Woodahl; Karla Claudio-Campos; Ann K Daly; Teri E Klein; Victoria M Pratt; Stuart A Scott; Andrea Gaedigk
Journal:  Clin Pharmacol Ther       Date:  2020-07-22       Impact factor: 6.875

6.  Identification of CYP2D6 Haplotypes that Interfere with Commonly Used Assays for Copy Number Variation Characterization.

Authors:  Amy J Turner; Praful Aggarwal; Erin C Boone; Cyrine-Eliana Haidar; Mary V Relling; Ashley D Derezinski; Ulrich Broeckel; Andrea Gaedigk
Journal:  J Mol Diagn       Date:  2021-02-22       Impact factor: 5.568

Review 7.  Pharmacogenetic factors affecting β-blocker metabolism and response.

Authors:  Cameron D Thomas; Julie A Johnson
Journal:  Expert Opin Drug Metab Toxicol       Date:  2020-09-09       Impact factor: 4.481

8.  CYP2D6 phenotype explains reported yohimbine concentrations in four severe acute intoxications.

Authors:  Anna Mueller-Schoell; Robin Michelet; Ferdinand Weinelt; Charlotte Kloft; Gerd Mikus
Journal:  Arch Toxicol       Date:  2021-05-24       Impact factor: 5.153

9.  CYP2D6 Phenotype Influences Aripiprazole Tolerability in Pediatric Patients with Mood Disorders.

Authors:  Sahar A Jallaq; Mark Verba; Jeffrey R Strawn; Lisa J Martin; Melissa P DelBello; Laura B Ramsey
Journal:  J Child Adolesc Psychopharmacol       Date:  2020-08-25       Impact factor: 2.576

10.  Computational Treatment Simulations to Assess the Need for Personalized Tamoxifen Dosing in Breast Cancer Patients of Different Biogeographical Groups.

Authors:  Anna Mueller-Schoell; Robin Michelet; Lena Klopp-Schulze; Madelé van Dyk; Thomas E Mürdter; Matthias Schwab; Markus Joerger; Wilhelm Huisinga; Gerd Mikus; Charlotte Kloft
Journal:  Cancers (Basel)       Date:  2021-05-18       Impact factor: 6.639
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