Literature DB >> 31543555

Exploring a Ring-Closing Metathesis Approach to the Archazolid Macrocycle.

Brianne R King1, Steven M Swick1, Sara L Schaefer1, Jamie R Welch1, Emily F Hunter1, Gregory W O'Neil1.   

Abstract

The synthesis of a new "eastern domain" of a proposed dihydroarchazolid analogue is described along with initial results from attempted macrocyclization by RCM. This work has revealed a competing backbiting process that may be preventable by alcohol functionalization and installation of a metathesis relay.

Entities:  

Keywords:  Natural products; Olefin metathesis; Relay ring-closing metathesis; Total synthesis

Year:  2014        PMID： 31543555      PMCID： PMC6754729          DOI： 10.1055/s-0034-1379003

Source DB:  PubMed          Journal:  Synthesis (Stuttg)        ISSN： 0039-7881            Impact factor:   3.157


  3 in total

1.  Synthesis of a C1-C23 fragment of the archazolids and evidence for V-ATPase but not COX inhibitory activity.

Authors:  Gregory W O'Neil; Alexander M Craig; John R Williams; Jeffrey C Young; P Clint Spiegel
Journal:  Synlett       Date:  2017-02-08       Impact factor: 2.454

2.  Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids.

Authors:  Solenne Rivière; Christin Vielmuth; Christiane Ennenbach; Aliaa Abdelrahman; Carina Lemke; Michael Gütschow; Christa E Müller; Dirk Menche
Journal:  ChemMedChem       Date:  2020-06-10       Impact factor: 3.466

Review 3.  Design and Synthesis of Simplified Polyketide Analogs: New Modalities beyond the Rule of 5.

Authors:  Dirk Menche
Journal:  ChemMedChem       Date:  2021-05-05       Impact factor: 3.466
  3 in total

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