| Literature DB >> 31543403 |
Jing Yuan1, Chen Chen2, Jinghua Cui3, Jing Lu4, Chao Yan3, Xiao Wei4, Xiangna Zhao4, NanNan Li3, Shaoli Li3, Guanhua Xue3, Weiwei Cheng4, Boxing Li4, Huan Li4, Weishi Lin4, Changyu Tian4, Jiangtao Zhao4, Juqiang Han5, Daizhi An4, Qiong Zhang2, Hong Wei6, Minghua Zheng7, Xuejun Ma8, Wei Li9, Xiao Chen3, Zheng Zhang3, Hui Zeng2, Sun Ying10, JianXin Wu3, Ruifu Yang11, Di Liu12.
Abstract
The underlying etiology of nonalcoholic fatty liver disease (NAFLD) is believed to be quite varied. Changes in the gut microbiota have been investigated and are believed to contribute to at least some cases of the disease, though a causal relationship remains unclear. Here, we show that high-alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) is associated with up to 60% of individuals with NAFLD in a Chinese cohort. Transfer of clinical isolates of HiAlc Kpn by oral gavage into mice induced NAFLD. Likewise, fecal microbiota transplant (FMT) into mice using a HiAlc-Kpn-strain-containing microbiota isolated from an individual with NASH induced NAFLD. However, selective elimination of the HiAlc Kpn strain before FMT prevented NAFLD in the recipient mice. These results suggest that at least in some cases of NAFLD an alteration in the gut microbiome drives the condition due to excess endogenous alcohol production.Entities:
Keywords: Klebsiella pneumoniae; alcohol-producing bacteria; endo-NAFLD; fatty liver disease; fecal microbiota transplantation; gut microbiota; high-fat diet; liver transcriptome; metagenomics; mice model
Year: 2019 PMID： 31543403 DOI： 10.1016/j.cmet.2019.08.018
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287