Hyunkyung Park1, Ja Min Byun2, Youngil Koh3, Sung-Soo Yoon4, Hyejoo Park5, Jayoun Lee6, Sang-Jin Shin6, Jeonghwan Youk7. 1. Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea. 2. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. Electronic address: jaminbyun@naver.com. 3. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. Electronic address: go01@snu.ac.kr. 4. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. 5. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. 6. National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea. 7. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Abstract
BACKGROUND: The optimal the conditioning regimens for allogeneic hematopoietic stem-cell transplantation, especially for East Asian patients, remains unknown. PATIENTS AND METHODS: We collected and analyzed clinical and survival data of 4255 patients from the Korean National Health Insurance Claims Database. RESULTS: Between 1562 myeloablative conditioning and 2693 nonmyeloablative conditioning groups, the overall survival was not statistically different. However, in the myeloablative conditioning group, the overall survival of the total body irradiation-based regimen was better than that of chemotherapy-alone regimen (P = .005). In subgroup analysis, the superiority of the total body irradiation-based regimen was especially prominent in acute leukemia (P = .012 for acute myeloid leukemia; P = .005 for acute lymphoblastic leukemia) and for younger patients (< 50 years old vs. ≥ 50 years old, P = .015). CONCLUSION: Total body irradiation combination might be the best conditioning regimen for young patients undergoing hematopoietic stem-cell transplantation for acute leukemias in Korea.
BACKGROUND: The optimal the conditioning regimens for allogeneic hematopoietic stem-cell transplantation, especially for East Asian patients, remains unknown. PATIENTS AND METHODS: We collected and analyzed clinical and survival data of 4255 patients from the Korean National Health Insurance Claims Database. RESULTS: Between 1562 myeloablative conditioning and 2693 nonmyeloablative conditioning groups, the overall survival was not statistically different. However, in the myeloablative conditioning group, the overall survival of the total body irradiation-based regimen was better than that of chemotherapy-alone regimen (P = .005). In subgroup analysis, the superiority of the total body irradiation-based regimen was especially prominent in acute leukemia (P = .012 for acute myeloid leukemia; P = .005 for acute lymphoblastic leukemia) and for younger patients (< 50 years old vs. ≥ 50 years old, P = .015). CONCLUSION: Total body irradiation combination might be the best conditioning regimen for young patients undergoing hematopoietic stem-cell transplantation for acute leukemias in Korea.
Authors: Jose R Teruel; Sameer Taneja; Paulina E Galavis; K Sunshine Osterman; Allison McCarthy; Martha Malin; Naamit K Gerber; Christine Hitchen; David L Barbee Journal: J Appl Clin Med Phys Date: 2021-02-10 Impact factor: 2.102