Jae-Min Kim1, Robert Stewart2, Ju-Wan Kim3, Hee-Ju Kang3, Sung-Wan Kim3, Il-Seon Shin3, Young Joon Hong4, Youngkeun Ahn4, Myung Ho Jeong4, Jin-Sang Yoon3. 1. Department of Psychiatry, Chonnam National University Medical School, Republic of Korea. Electronic address: jmkim@chonnam.ac.kr. 2. King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK; South London and Maudsley NHS Foundation Trust, London, UK. 3. Department of Psychiatry, Chonnam National University Medical School, Republic of Korea. 4. Department of Cardiology, Chonnam National University Medical School, Republic of Korea.
Abstract
BACKGROUND: Depression has been associated with worse cardiac outcomes in patients with acute coronary syndrome, while no study has investigated trajectory of depression and ACS prognosis. This study investigated associations of depressive disorder within 2 weeks (early) and at 1 year (late) after ACS with major adverse cardiac event (MACE). METHOD: In 757 ACS patients recruited in 2007-2012 and evaluated for depressive disorder at the two time-points, 5-12 year follow-up for MACE was conducted. RESULTS: MACE incidence was significantly higher in patients with depressive disorder at early or late phase of ACS than those without, regardless of status at the other time point; however, highest incidence was found following depression at both time points. LIMITATION: The follow-up for depressive disorder was made at only one point. CONCLUSION: Depression evaluation thus needs consideration both early and late post-ACS.
BACKGROUND:Depression has been associated with worse cardiac outcomes in patients with acute coronary syndrome, while no study has investigated trajectory of depression and ACS prognosis. This study investigated associations of depressive disorder within 2 weeks (early) and at 1 year (late) after ACS with major adverse cardiac event (MACE). METHOD: In 757 ACSpatients recruited in 2007-2012 and evaluated for depressive disorder at the two time-points, 5-12 year follow-up for MACE was conducted. RESULTS: MACE incidence was significantly higher in patients with depressive disorder at early or late phase of ACS than those without, regardless of status at the other time point; however, highest incidence was found following depression at both time points. LIMITATION: The follow-up for depressive disorder was made at only one point. CONCLUSION:Depression evaluation thus needs consideration both early and late post-ACS.