Masafumi Oda1, Pedro V Staziaki2, Muhammad M Qureshi3, V Carlota Andreu-Arasa2, Baojun Li2, Koji Takumi4, Margaret N Chapman2, Albert Wang2, Andrew R Salama5, Osamu Sakai6. 1. Department of Radiology, Boston Medical Center, Boston University School of Medicine, United States; Division of Oral and Maxillofacial Radiology, Kyushu Dental University, Kitakyushu, Fukuoka, Japan. 2. Department of Radiology, Boston Medical Center, Boston University School of Medicine, United States. 3. Department of Radiology, Boston Medical Center, Boston University School of Medicine, United States; Deparment of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, United States. 4. Department of Radiology, Boston Medical Center, Boston University School of Medicine, United States; Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. 5. Deparment of Otolaryngology - Head and Neck Surgery, Boston Medical Center, Boston University School of Medicine, United States; Department of Oral & Maxillofacial Surgery, Boston Medical Center, Boston University Henry M. Goldman School of Dental Medicine, United States. 6. Department of Radiology, Boston Medical Center, Boston University School of Medicine, United States; Deparment of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, United States; Deparment of Otolaryngology - Head and Neck Surgery, Boston Medical Center, Boston University School of Medicine, United States. Electronic address: osamu.sakai@bmc.org.
Abstract
PURPOSE: Cystic and cystic-appearing odontogenic lesions of the jaw may appear similar on CT imaging. Accurate diagnosis is often difficult although the relationship of the lesion to the tooth root or crown may offer a clue to the etiology. The purpose of this study was to evaluate CT texture analysis as an aid in differentiating cystic and cystic-appearing odontogenic lesions of the jaw. METHODS: This was an IRB-approved retrospective study including 42 pathology-proven dentigerous cysts, 37 odontogenic keratocysts, and 19 ameloblastomas. Each lesion was manually segmented on axial CT images, and textural features were analyzed using an in-house-developed Matlab-based texture analysis program that extracted 47 texture features from each segmented volume. Statistical analysis was performed comparing all pairs of the three types of lesions. RESULTS: Pairwise analysis revealed that nine histogram features, one GLCM feature, three GLRL features, two Laws features, four GLGM features and two Chi-square features showed significant differences between dentigerous cysts and odontogenic keratocysts. Four histogram features and one Chi-square feature showed significant differences between odontogenic keratocysts and ameloblastomas. Two histogram features showed significant differences between dentigerous cysts and ameloblastomas. CONCLUSIONS: CT texture analysis may be useful as a noninvasive method to obtain additional quantitative information to differentiate cystic and cystic-appearing odontogenic lesions of the jaw.
PURPOSE: Cystic and cystic-appearing odontogenic lesions of the jaw may appear similar on CT imaging. Accurate diagnosis is often difficult although the relationship of the lesion to the tooth root or crown may offer a clue to the etiology. The purpose of this study was to evaluate CT texture analysis as an aid in differentiating cystic and cystic-appearing odontogenic lesions of the jaw. METHODS: This was an IRB-approved retrospective study including 42 pathology-proven dentigerous cysts, 37 odontogenic keratocysts, and 19 ameloblastomas. Each lesion was manually segmented on axial CT images, and textural features were analyzed using an in-house-developed Matlab-based texture analysis program that extracted 47 texture features from each segmented volume. Statistical analysis was performed comparing all pairs of the three types of lesions. RESULTS: Pairwise analysis revealed that nine histogram features, one GLCM feature, three GLRL features, two Laws features, four GLGM features and two Chi-square features showed significant differences between dentigerous cysts and odontogenic keratocysts. Four histogram features and one Chi-square feature showed significant differences between odontogenic keratocysts and ameloblastomas. Two histogram features showed significant differences between dentigerous cysts and ameloblastomas. CONCLUSIONS: CT texture analysis may be useful as a noninvasive method to obtain additional quantitative information to differentiate cystic and cystic-appearing odontogenic lesions of the jaw.
Authors: Catharina Simioni De Rosa; Mariana Lobo Bergamini; Michelle Palmieri; Dmitry José de Santana Sarmento; Marcia Oliveira de Carvalho; Ana Lúcia Franco Ricardo; Bengt Hasseus; Peter Jonasson; Paulo Henrique Braz-Silva; Andre Luiz Ferreira Costa Journal: Heliyon Date: 2020-10-09