| Literature DB >> 31539503 |
William P Katt1, Michael J Lukey1, Richard A Cerione2.
Abstract
Increased consumption of glucose and glutamine are metabolic hallmarks of tumorigenesis. In this issue of Cell Chemical Biology, Reckzeh et al. (2019) describe the discovery of Glutor, a potent inhibitor of cellular glucose uptake. Combining Glutor with the glutaminase inhibitor CB-839 creates a metabolic crisis in cancer cells, synergistically impeding proliferation.Entities:
Year: 2019 PMID： 31539503 DOI： 10.1016/j.chembiol.2019.09.005
Source DB: PubMed Journal: Cell Chem Biol ISSN： 2451-9448 Impact factor: 8.116