| Literature DB >> 31538480 |
Jiabin Ni1,2, Bekzod Nishonov1,2, Azizbek Pardaev1,2, Ao Zhang1,2,3.
Abstract
A Pd-catalyzed ring-opening sulfonylation of gem-difluorocyclopropanes is reported. This protocol involves C-C bond cleavage, β-F elimination, and allylic coupling to form corresponding 2-fluoroallylic sulfones efficiently with Z-selectivity. Different substrates bearing diverse functional groups are tolerated. Moreover, this method is successfully used for the late-stage derivation of several bioactive molecules.Entities:
Year: 2019 PMID： 31538480 DOI： 10.1021/acs.joc.9b01897
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354