Literature DB >> 31538262

D-Galactose-induced accelerated aging model: an overview.

Khairunnuur Fairuz Azman1, Rahimah Zakaria2.   

Abstract

To facilitate the process of aging healthily and prevent age-related health problems, efforts to properly understand aging mechanisms and develop effective and affordable anti-aging interventions are deemed necessary. Systemic administration of D-galactose has been established to artificially induce senescence in vitro and in vivo as well as for anti-aging therapeutic interventions studies. The aim of this article is to comprehensively discuss the use of D-galactose to generate a model of accelerated aging and its possible underlying mechanisms involved in different tissues/organs.

Entities:  

Keywords:  Aging model; Anti-aging; D-Galactose; Senescence

Mesh：

Substances：

Year:  2019        PMID： 31538262     DOI： 10.1007/s10522-019-09837-y

Source DB:  PubMed          Journal:  Biogerontology        ISSN： 1389-5729            Impact factor:   4.277


  44 in total

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2.  K63 Ubiquitination of P21 Can Facilitate Pellino-1 in the Context of Chronic Obstructive Pulmonary Disease and Lung Cellular Senescence.

Authors:  Jia-Hui Ma; Yi-Ting Zhang; Lu-Ping Wang; Qing-Yu Sun; Hao Zhang; Jian-Jiang Li; Ning-Ning Han; Yao-Yao Zhu; Xiao-Yu Xie; Xia Li
Journal:  Cells       Date:  2022-10-03       Impact factor: 7.666

3.  Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and D-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging.

Authors:  Sandeep Singh; Raushan Kumar; Geetika Garg; Abhishek Kumar Singh; Avnish Kumar Verma; Akalabya Bissoyi; Syed Ibrahim Rizvi
Journal:  Biogerontology       Date:  2020-09-26       Impact factor: 4.277

4.  Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress.

Authors:  Elham Hakimizadeh; Mohammad Zamanian; Lydia Giménez-Llort; Clara Sciorati; Marjan Nikbakhtzadeh; Małgorzata Kujawska; Ayat Kaeidi; Jalal Hassanshahi; Iman Fatemi
Journal:  Antioxidants (Basel)       Date:  2021-04-23

5.  Acer Truncatum Seed Oil Alleviates Learning and Memory Impairments of Aging Mice.

Authors:  Xiao Li; Ting Li; Xiao Yue Hong; Jian Jun Liu; Xi Fei Yang; Gong Ping Liu
Journal:  Front Cell Dev Biol       Date:  2021-05-14

6.  Preventive electroacupuncture ameliorates D-galactose-induced Alzheimer's disease-like inflammation and memory deficits, probably via modulating the microbiota-gut-brain axis.

Authors:  Chuan He; Zhong-Sheng Huang; Chao-Chao Yu; Xue-Song Wang; Tao Jiang; Miao Wu; Li-Hong Kong
Journal:  Iran J Basic Med Sci       Date:  2021-03       Impact factor: 2.699

7.  An essay on the nominal vs. real definitions of aging.

Authors:  Aleksei G Golubev
Journal:  Biogerontology       Date:  2021-06-06       Impact factor: 4.277

8.  A Novel Biochemical Study of Anti-Dermal Fibroblast Replicative Senescence Potential of Panax Notoginseng Oligosaccharides.

Authors:  Lu Zhai; Xiaohao Xu; Jiangzeng Liu; Chenxu Jing; Xinzhao Yang; Daqing Zhao; Rui Jiang; Li-Wei Sun
Journal:  Front Pharmacol       Date:  2021-06-30       Impact factor: 5.810

9.  Licochalcone D Ameliorates Oxidative Stress-Induced Senescence via AMPK Activation.

Authors:  Nagarajan Maharajan; Chitra Devi Ganesan; Changjong Moon; Chul-Ho Jang; Won-Keun Oh; Gwang-Won Cho
Journal:  Int J Mol Sci       Date:  2021-07-07       Impact factor: 5.923

10.  Pentoxifylline Enhances Antioxidative Capability and Promotes Mitochondrial Biogenesis in D-Galactose-Induced Aging Mice by Increasing Nrf2 and PGC-1α through the cAMP-CREB Pathway.

Authors:  Yu Wang; Tianyun Zhang; Hui Zhao; Chunxiao Qi; Xiaoming Ji; Hexin Yan; Rui Cui; Guoliang Zhang; Yunxiao Kang; Geming Shi
Journal:  Oxid Med Cell Longev       Date:  2021-06-22       Impact factor: 6.543
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