| Literature DB >> 31536954 |
Lijun An1, Yue Liang1, Xueyuan Yang1, Huimei Wang1, Jie Zhang2, Muhetaer Tuerhong3, Dihua Li4, Chunyan Wang5, Dongho Lee6, Jing Xu7, Ling Shuai1, Jin Jin1, Yuanqiang Guo8.
Abstract
Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3-5), and seven known analogues (6-12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50 values less than 40 μM. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.Entities:
Keywords: Diterpenoids; Euphorbia antiquorum; Inflammation; Molecular docking; NO inhibitory effects
Year: 2019 PMID： 31536954 DOI： 10.1016/j.bioorg.2019.103237
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275