Seung Won Lee1, Dong Keon Yon2, Chase C James3, Shinhae Lee4, Hyun Yong Koh5, Youn Ho Sheen6, Jae-Won Oh7, Man Yong Han8, George Sugihara3. 1. Graduate School of Medicine, CHA University, Seongnam, Korea; Department of Data Science, Sejong University College of Software Convergence, Seoul, Korea. 2. Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea; Medical Corps, Republic of Korea Army, Seongnam, Korea. 3. Scripps Institution of Oceanography, University of California San Diego, San Diego, Calif. 4. Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea. 5. F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Mass. 6. Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea. 7. Department of Pediatrics, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea. 8. Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea. Electronic address: drmesh@gmail.com.
Abstract
BACKGROUND: Although the different age groups had differences in sensitivity of asthma exacerbations (AEs) to environmental factors, no comprehensive study has examined the age-stratified effects of environmental factors on AEs. OBJECTIVE: We sought to examine the short-term effects in age-stratified groups (infants, preschool children, school-aged children, adults, and the elderly) of outdoor environmental factors (air pollutants, weather conditions, aeroallergens, and respiratory viral epidemics) on AEs. METHODS: We performed an age-stratified analysis of the short-term effects of 4 groups of outdoor environmental factors on AEs in Seoul Metropolitan City (Korea) from 2008 and 2012. The statistical analysis used a Poisson generalized linear regression model, with a distributed lag nonlinear model for identification of lagged and nonlinear effects and convergent cross-mapping for identification of causal associations. RESULTS: Analysis of the total population (n = 10,233,519) indicated there were 28,824 AE events requiring admission to an emergency department during the study period. Diurnal temperature range had significant effects in pediatric (infants, preschool children, and school-aged children) and elderly (relative risk [RR], 1.056-1.078 and 1.016, respectively) subjects. Tree and weed pollen, human rhinovirus, and influenza virus had significant effects in school-aged children (RR, 1.014, 1.040, 1.042, and 1.038, respectively). Tree pollen and influenza virus had significant effects in adults (RR, 1.026 and 1.044, respectively). Outdoor air pollutants (particulate matter of ≤10 μm in diameter, nitrogen dioxide, ozone, carbon monoxide, and sulfur dioxide) had significant short-term effects in all age groups (except for carbon monoxide and sulfur dioxide in infants). CONCLUSION: These findings provide a need for the development of tailored strategies to prevent AE events in different age groups.
BACKGROUND: Although the different age groups had differences in sensitivity of asthma exacerbations (AEs) to environmental factors, no comprehensive study has examined the age-stratified effects of environmental factors on AEs. OBJECTIVE: We sought to examine the short-term effects in age-stratified groups (infants, preschool children, school-aged children, adults, and the elderly) of outdoor environmental factors (air pollutants, weather conditions, aeroallergens, and respiratory viral epidemics) on AEs. METHODS: We performed an age-stratified analysis of the short-term effects of 4 groups of outdoor environmental factors on AEs in Seoul Metropolitan City (Korea) from 2008 and 2012. The statistical analysis used a Poisson generalized linear regression model, with a distributed lag nonlinear model for identification of lagged and nonlinear effects and convergent cross-mapping for identification of causal associations. RESULTS: Analysis of the total population (n = 10,233,519) indicated there were 28,824 AE events requiring admission to an emergency department during the study period. Diurnal temperature range had significant effects in pediatric (infants, preschool children, and school-aged children) and elderly (relative risk [RR], 1.056-1.078 and 1.016, respectively) subjects. Tree and weed pollen, human rhinovirus, and influenza virus had significant effects in school-aged children (RR, 1.014, 1.040, 1.042, and 1.038, respectively). Tree pollen and influenza virus had significant effects in adults (RR, 1.026 and 1.044, respectively). Outdoor air pollutants (particulate matter of ≤10 μm in diameter, nitrogen dioxide, ozone, carbon monoxide, and sulfur dioxide) had significant short-term effects in all age groups (except for carbon monoxide and sulfur dioxide in infants). CONCLUSION: These findings provide a need for the development of tailored strategies to prevent AE events in different age groups.
Authors: Nur Sabrina Idrose; Caroline J Lodge; Bircan Erbas; Jo A Douglass; Dinh S Bui; Shyamali C Dharmage Journal: Int J Environ Res Public Health Date: 2022-06-20 Impact factor: 4.614
Authors: Piotr Dąbrowiecki; Andrzej Chciałowski; Agata Dąbrowiecka; Artur Badyda Journal: Int J Environ Res Public Health Date: 2022-05-14 Impact factor: 4.614
Authors: Athanasios Damialis; Stefanie Gilles; Mikhail Sofiev; Viktoria Sofieva; Franziska Kolek; Daniela Bayr; Maria P Plaza; Vivien Leier-Wirtz; Sigrid Kaschuba; Lewis H Ziska; Leonard Bielory; László Makra; Maria Del Mar Trigo; Claudia Traidl-Hoffmann Journal: Proc Natl Acad Sci U S A Date: 2021-03-23 Impact factor: 11.205