Patrick Meybohm1, Hendrik Kohlhof2, Dieter Christian Wirtz2, Ingo Marzi3, Christoph Füllenbach1, Suma Choorapoikayil1, Maria Wittmann4, Ursula Marschall5, Josef Thoma6, Klaus Schwendner7, Patrick Stark8, Ansgar Raadts9, Jens Friedrich10, Henry Weigt11, Patrick Friederich12, Josef Huber13, Martin Gutjahr14, Elke Schmitt1,15, Kai Zacharowski1. 1. Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt. 2. Department of Orthopedics and Trauma Surgery, University Hospital Bonn. 3. Department of Trauma, Hand and Reconstructive Surgery, University Hospital Frankfurt am Main. 4. Department of Anesthesiology and Operative Intensive Care Medicine, University Hospital Bonn. 5. Head of Department Medicine/Health Care Research, Barmer, Wuppertal. 6. Department of Anesthesiology and Operative Intensive Medicine, ORTENAU KLINIKUM Offenburg-Kehl, Offenburg. 7. Department of Anesthesiology and Operative Intensive Care Medicine, Martha-Maria Hospital Nuremberg. 8. Department of Visceral and Vascular Surgery, Klinikum Mittelmosel, Zell. 9. Department of Anesthesiology and Intensive Care Medicine, University Hospital Jena. 10. Department of Anesthesiology and Operative Intensive Care Medicine, Klinikum Leverkusen gGmbH. 11. Department of Anesthesiology, SLK-Kliniken Heilbronn GmbH. 12. Department of Anesthesiology, Operative Intensive Medicine and Pain Therapy, München Klinik Bogenhausen. 13. Institute for Laboratory Diagnostics and Transfusion Medicine, Donauisar Klinikum Deggendorf. 14. Department for Anesthesiology, Intensive Medicine and Pain Therapy, Marienhausklinik Ottweiler. 15. Institute for Biostatistics and Mathematical Modelling, Goethe University Frankfurt.
Abstract
INTRODUCTION: Approximately one in three patients has untreated preoperative anaemia, which in turn is associated with an increased need for transfusion of allogenic red blood cell concentrates (RBC) and complications in the context of a surgical intervention. Here, the prevalence of preoperative and postoperative anaemia as well as their effects on transfusion rate, hospital length of stay and hospital mortality in primary hip and knee arthroplasty has been analysed. METHODS: From January 2012 to September 2018, 378,069 adult inpatients from 13 German hospitals were analysed on the basis of an anonymized registry. Of these, n = 10,017 patients had a hip and knee joint primary arthroplasty. The primary endpoint was the incidence of preoperative anaemia, which was analysed by the first available preoperative haemoglobin value according to the WHO definition. Secondary endpoints included in-hospital length of stay, number of patients with red blood cell concentrate transfusion, incidence of hospital-acquired anaemia, number of deceased patients, and postoperative complications. RESULTS: The preoperative anaemia rate was 14.8% for elective knee joint arthroplasty, 22.9% for elective hip joint arthroplasty and 45.0% for duo-prosthesis implantation. Preoperative anaemia led to a significantly higher transfusion rate (knee: 8.3 vs. 1.8%; hip: 34.5 vs. 8.1%; duo-prosthesis: 42.3 vs. 17.4%), an increased red blood cell concentrate consumption (knee: 256 ± 107 vs. 29 ± 5 RBC/1000 patients; hip: 929 ± 60 vs. 190 ± 16 RBC/1000 patients; duo-prosthesis: 1411 ± 98 vs. 453 ± 42 RBC/1000 patients). Pre-operative anaemia was associated with prolonged hospital stay (12.0 [10.0; 17.0] d vs. 11.0 [9.0; 13.0] d; p < 0.001) and increased mortality (5.5% [4.6 - 6.5%] vs. 0.9% [0.7 - 1.2%]; Fisher p < 0.001) compared to non-anaemic patients. In patients aged 80 years and older, the incidence of preoperative anaemia and thus the transfusion rate was almost twice as high as in patients under 80 years of age. SUMMARY: Preoperative anaemia is common in knee and hip primary arthroplasty and was associated with a relevant increase in red blood cell concentrate consumption. In the context of patient blood management, a relevant potential arises, especially in elective orthopaedic surgery, to better prepare elective patients, to avoid unnecessary transfusions and thus to conserve the valuable resource blood. Georg Thieme Verlag KG Stuttgart · New York.
INTRODUCTION: Approximately one in three patients has untreated preoperative anaemia, which in turn is associated with an increased need for transfusion of allogenic red blood cell concentrates (RBC) and complications in the context of a surgical intervention. Here, the prevalence of preoperative and postoperative anaemia as well as their effects on transfusion rate, hospital length of stay and hospital mortality in primary hip and knee arthroplasty has been analysed. METHODS: From January 2012 to September 2018, 378,069 adult inpatients from 13 German hospitals were analysed on the basis of an anonymized registry. Of these, n = 10,017 patients had a hip and knee joint primary arthroplasty. The primary endpoint was the incidence of preoperative anaemia, which was analysed by the first available preoperative haemoglobin value according to the WHO definition. Secondary endpoints included in-hospital length of stay, number of patients with red blood cell concentrate transfusion, incidence of hospital-acquired anaemia, number of deceased patients, and postoperative complications. RESULTS: The preoperative anaemia rate was 14.8% for elective knee joint arthroplasty, 22.9% for elective hip joint arthroplasty and 45.0% for duo-prosthesis implantation. Preoperative anaemia led to a significantly higher transfusion rate (knee: 8.3 vs. 1.8%; hip: 34.5 vs. 8.1%; duo-prosthesis: 42.3 vs. 17.4%), an increased red blood cell concentrate consumption (knee: 256 ± 107 vs. 29 ± 5 RBC/1000 patients; hip: 929 ± 60 vs. 190 ± 16 RBC/1000 patients; duo-prosthesis: 1411 ± 98 vs. 453 ± 42 RBC/1000 patients). Pre-operative anaemia was associated with prolonged hospital stay (12.0 [10.0; 17.0] d vs. 11.0 [9.0; 13.0] d; p < 0.001) and increased mortality (5.5% [4.6 - 6.5%] vs. 0.9% [0.7 - 1.2%]; Fisher p < 0.001) compared to non-anaemic patients. In patients aged 80 years and older, the incidence of preoperative anaemia and thus the transfusion rate was almost twice as high as in patients under 80 years of age. SUMMARY: Preoperative anaemia is common in knee and hip primary arthroplasty and was associated with a relevant increase in red blood cell concentrate consumption. In the context of patient blood management, a relevant potential arises, especially in elective orthopaedic surgery, to better prepare elective patients, to avoid unnecessary transfusions and thus to conserve the valuable resource blood. Georg Thieme Verlag KG Stuttgart · New York.
Authors: Aoife MacMahon; Sandesh S Rao; Yash P Chaudhry; Syed A Hasan; Jeremy A Epstein; Vishal Hegde; Daniel J Valaik; Julius K Oni; Robert S Sterling; Harpal S Khanuja Journal: HSS J Date: 2021-07-30