Kim Wiegertjes1, Annemieke Ter Telgte1, Pedro B Oliveira1, Esther M C van Leijsen1, Mayra I Bergkamp1, Ingeborg W M van Uden1, Mohsen Ghafoorian1, Helena M van der Holst1, David G Norris1, Bram Platel1, Catharina J M Klijn1, Anil M Tuladhar1, Frank-Erik de Leeuw2. 1. From the Department of Neurology (K.W., A.t.T., P.B.O., E.M.C.v.L., M.I.B., I.W.M.v.U., H.M.v.d.H., C.J.M.K., A.M.T., F.-E.d.L.) and Center for Cognitive Neuroimaging (D.G.N.), Donders Institute for Brain, Cognition and Behavior, and Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine (M.G., B.P.), Radboud University Medical Center; and Institute for Computing and Information Sciences (M.G.), Radboud University, Nijmegen, the Netherlands. 2. From the Department of Neurology (K.W., A.t.T., P.B.O., E.M.C.v.L., M.I.B., I.W.M.v.U., H.M.v.d.H., C.J.M.K., A.M.T., F.-E.d.L.) and Center for Cognitive Neuroimaging (D.G.N.), Donders Institute for Brain, Cognition and Behavior, and Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine (M.G., B.P.), Radboud University Medical Center; and Institute for Computing and Information Sciences (M.G.), Radboud University, Nijmegen, the Netherlands. FrankErik.deLeeuw@radboudumc.nl.
Abstract
OBJECTIVE: To investigate the prevalence of asymptomatic diffusion-weighted imaging-positive (DWI+) lesions in individuals with cerebral small vessel disease (SVD) and identify their role in the origin of SVD markers on MRI. METHODS: We included 503 individuals with SVD from the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort (RUN DMC) study (mean age 65.6 years [SD 8.8], 56.5% male) with 1.5T MRI in 2006 and, if available, follow-up MRI in 2011 and 2015. We screened DWI scans (n = 1,152) for DWI+ lesions, assessed lesion evolution on follow-up fluid-attenuated inversion recovery, T1 and T2* images, and examined the association between DWI+ lesions and annual SVD progression (white matter hyperintensities [WMH], lacunes, microbleeds). RESULTS: We found 50 DWI+ lesions in 39 individuals on 1,152 DWI (3.4%). Individuals with DWI+ lesions were older (p = 0.025), more frequently had a history of hypertension (p = 0.021), and had a larger burden of preexisting SVD MRI markers (WMH, lacunes, microbleeds: all p < 0.001) compared to individuals without DWI+ lesions. Of the 23 DWI+ lesions with available follow-up MRI, 14 (61%) evolved into a WMH, 8 (35%) resulted in a cavity, and 1 (4%) was no longer visible. Presence of DWI+ lesions was significantly associated with annual WMH volume increase and yearly incidence of lacunes and microbleeds (all p < 0.001). CONCLUSION: Over 3% of individuals with SVD have DWI+ lesions. Although DWI+ lesions play a role in the progression of SVD, they may not fully explain progression of SVD markers on MRI, suggesting that other factors than acute ischemia are at play.
OBJECTIVE: To investigate the prevalence of asymptomatic diffusion-weighted imaging-positive (DWI+) lesions in individuals with cerebral small vessel disease (SVD) and identify their role in the origin of SVD markers on MRI. METHODS: We included 503 individuals with SVD from the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort (RUN DMC) study (mean age 65.6 years [SD 8.8], 56.5% male) with 1.5T MRI in 2006 and, if available, follow-up MRI in 2011 and 2015. We screened DWI scans (n = 1,152) for DWI+ lesions, assessed lesion evolution on follow-up fluid-attenuated inversion recovery, T1 and T2* images, and examined the association between DWI+ lesions and annual SVD progression (white matter hyperintensities [WMH], lacunes, microbleeds). RESULTS: We found 50 DWI+ lesions in 39 individuals on 1,152 DWI (3.4%). Individuals with DWI+ lesions were older (p = 0.025), more frequently had a history of hypertension (p = 0.021), and had a larger burden of preexisting SVD MRI markers (WMH, lacunes, microbleeds: all p < 0.001) compared to individuals without DWI+ lesions. Of the 23 DWI+ lesions with available follow-up MRI, 14 (61%) evolved into a WMH, 8 (35%) resulted in a cavity, and 1 (4%) was no longer visible. Presence of DWI+ lesions was significantly associated with annual WMH volume increase and yearly incidence of lacunes and microbleeds (all p < 0.001). CONCLUSION: Over 3% of individuals with SVD have DWI+ lesions. Although DWI+ lesions play a role in the progression of SVD, they may not fully explain progression of SVD markers on MRI, suggesting that other factors than acute ischemia are at play.
Authors: Annemieke Ter Telgte; Ashley A Scherlek; Yael D Reijmer; Andre J van der Kouwe; Thijs van Harten; Marco Duering; Brian J Bacskai; Frank-Erik de Leeuw; Matthew P Frosch; Steven M Greenberg; Susanne J van Veluw Journal: Acta Neuropathol Date: 2020-02-27 Impact factor: 17.088
Authors: Michelle G Jansen; Ludovica Griffanti; Clare E Mackay; Melis Anatürk; Luca Melazzini; Ann-Marie G de Lange; Nicola Filippini; Enikő Zsoldos; Kim Wiegertjes; Frank-Erik de Leeuw; Archana Singh-Manoux; Mika Kivimäki; Klaus P Ebmeier; Sana Suri Journal: J Cereb Blood Flow Metab Date: 2021-10-05 Impact factor: 6.960
Authors: Marlies P Noz; Annemieke Ter Telgte; Kim Wiegertjes; Anil M Tuladhar; Charlotte Kaffa; Simone Kersten; Siroon Bekkering; Charlotte D C C van der Heijden; Alexander Hoischen; Leo A B Joosten; Mihai G Netea; Marco Duering; Frank-Erik de Leeuw; Niels P Riksen Journal: Front Cardiovasc Med Date: 2021-05-13
Authors: Bruno M de Brito Robalo; Geert Jan Biessels; Christopher Chen; Anna Dewenter; Marco Duering; Saima Hilal; Huiberdina L Koek; Anna Kopczak; Bonnie Yin Ka Lam; Alexander Leemans; Vincent Mok; Laurien P Onkenhout; Hilde van den Brink; Alberto de Luca Journal: Neuroimage Clin Date: 2021-11-18 Impact factor: 4.881
Authors: Kim Wiegertjes; Sabine Voigt; Wilmar M T Jolink; Emma A Koemans; Floris H B M Schreuder; Marianne A A van Walderveen; Marieke J H Wermer; Frederick J A Meijer; Marco Duering; Frank-Erik de Leeuw; Catharina J M Klijn Journal: Front Neurol Date: 2022-06-15 Impact factor: 4.086