Han Shi1, Hanze Chen2, Yun Zhang1, Jinwei Li2, Kailei Fu2, Weishuang Xue2, Weiyu Teng3, Li Tian4. 1. Clinical Department One, China Medical University, Shenyang, China. 2. Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, China. 3. Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, China. Electronic address: tengweiyucmu@sina.com. 4. Department of Geriatrics, Shengjing Hospital, China Medical University, Shenyang, China. Electronic address: tianlicmu2@126.com.
Abstract
BACKGROUND & AIMS: A growing number of studies have shown that vitamin D are related to the risk of stroke, however, the dose-response association between vitamin D and the risk of stroke is still unclear. Accordingly, we conducted a dose-response meta-analysis to evaluate the relationships between 25-hydroxyvitamin D [25(OH)D] level, vitamin D intake, and the risk of stroke by summarizing cohort studies. METHODS: PubMed, Embase, Cochrane and the Web of Science database were searched for related studies. Cohort studies examining the influence of 25(OH)D level and vitamin D intake on stroke risk were summarized. Dose-response relationships were determined using a random-effect model. RESULTS: Twenty cohort studies involving 217,235 participants were included. The pooled relative risk for the high-versus-low categories was 0.74 (95% CI: 0.66-0.83) for 25(OH)D level, and 0.75 (95% CI: 0.57-0.98) for vitamin D intake. In addition, there were non-linear relationships between 25(OH)D level, vitamin D intake, and stroke risk. The incidence of stroke was reduced to its lowest point, with a reduction of about 20%, when 25(OH)D level was about 50 nmol/L or vitamin D intake was about 12 μg/day. CONCLUSION: 25(OH)D level and vitamin D intake were both inversely related to stroke risk, with a non-linear dose-response relationship.
BACKGROUND & AIMS: A growing number of studies have shown that vitamin D are related to the risk of stroke, however, the dose-response association between vitamin D and the risk of stroke is still unclear. Accordingly, we conducted a dose-response meta-analysis to evaluate the relationships between 25-hydroxyvitamin D [25(OH)D] level, vitamin D intake, and the risk of stroke by summarizing cohort studies. METHODS: PubMed, Embase, Cochrane and the Web of Science database were searched for related studies. Cohort studies examining the influence of 25(OH)D level and vitamin D intake on stroke risk were summarized. Dose-response relationships were determined using a random-effect model. RESULTS: Twenty cohort studies involving 217,235 participants were included. The pooled relative risk for the high-versus-low categories was 0.74 (95% CI: 0.66-0.83) for 25(OH)D level, and 0.75 (95% CI: 0.57-0.98) for vitamin D intake. In addition, there were non-linear relationships between 25(OH)D level, vitamin D intake, and stroke risk. The incidence of stroke was reduced to its lowest point, with a reduction of about 20%, when 25(OH)D level was about 50 nmol/L or vitamin D intake was about 12 μg/day. CONCLUSION:25(OH)D level and vitamin D intake were both inversely related to stroke risk, with a non-linear dose-response relationship.
Authors: Abdullah R Alharbi; Amer S Alali; Yahya Samman; Nouf A Alghamdi; Omar Albaradie; Maan Almaghrabi; Seraj Makkawi; Saeed Alghamdi; Mohammad S Alzahrani; Mohammed Alsalmi; Vardan T Karamyan; Khalid Al Sulaiman; Ohoud Aljuhani; Faisal F Alamri Journal: Front Neurosci Date: 2022-07-27 Impact factor: 5.152